Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Mar;46(2):129-137.
doi: 10.1007/s00059-021-05020-7. Epub 2021 Jan 27.

Neglected cardiovascular diseases and their significance in the Global North

Affiliations
Review

Neglected cardiovascular diseases and their significance in the Global North

Charle André Viljoen et al. Herz. 2021 Mar.

Abstract

Due to increasing global migration, the spectrum of cardiovascular disease (CVD) is changing in developed countries. Up to 3% of migrants arriving in Europe have underlying CVD. Despite their high global prevalence, conditions such as rheumatic heart disease, Chagas disease, endomyocardial fibrosis, tuberculous pericarditis, peripartum cardiomyopathy, and pulmonary hypertension are often under-recognized, and, as a result, neglected in industrialized countries. Many of these conditions, and their causes, are often unfamiliar to the health-care providers in host countries. In this review, we summarize the epidemiology, etiology, clinical presentation, diagnostic work-up, and management of neglected CVDs that have an increasing prevalence in the Global North.

Durch die Zunahme der globalen Migration ändert sich auch das Spektrum von kardiovaskulären Erkrankungen im globalen Norden (d. h. in industrialisierten Ländern). Bis zu 3 % der in Europa eintreffenden Migranten weisen kardiovaskuläre Vorerkrankungen auf. Trotz ihrer hohen globalen Prävalenz bleiben kardiovaskuläre Krankheitsbilder wie die rheumatische Herzerkrankung, Chagas-Krankheit, endomyokardiale Fibrose, tuberkulöse Perikarditis, peripartale Kardiomyopathie und pulmonale Hypertonie häufig unerkannt und werden daher in Industrienationen als vernachlässigbar eingestuft. Viele dieser Erkrankungen und ihre Ursachen sind dem Gesundheitswesen im globalen Norden nur unzureichend bekannt. Im vorliegenden Übersichtsartikel werden die Epidemiologie, Ätiologie, klinische Präsentation, Diagnostik und Therapie von häufigen kardiovaskulären Erkrankungen im globalen Süden zusammengefasst, welche aufgrund der zunehmenden Migration und Globalisierung eine zunehmende Prävalenz in der westlichen Welt aufweisen.

Keywords: Chagas disease; Endomyocardial fibrosis; Pulmonary hypertension; Rheumatic heart disease; Tuberculous pericarditis.

PubMed Disclaimer

Similar articles

Cited by

  • Diagnosis of Tuberculous Pericarditis in Zhejiang, China: A Diagnostic Prediction Model Based on LASSO Logistic Regression.
    Xu X, Liu X, Yang C, Cai L, Liu L, Chen T, Zhu H, Wei H. Xu X, et al. J Inflamm Res. 2025 Apr 3;18:4681-4693. doi: 10.2147/JIR.S504183. eCollection 2025. J Inflamm Res. 2025. PMID: 40195957 Free PMC article.
  • SBC Guideline on the Diagnosis and Treatment of Patients with Cardiomyopathy of Chagas Disease - 2023.
    Marin-Neto JA, Rassi A Jr, Oliveira GMM, Correia LCL, Ramos Júnior AN, Luquetti AO, Hasslocher-Moreno AM, Sousa AS, Paola AAV, Sousa ACS, Ribeiro ALP, Correia Filho D, Souza DDSM, Cunha-Neto E, Ramires FJA, Bacal F, Nunes MDCP, Martinelli Filho M, Scanavacca MI, Saraiva RM, Oliveira Júnior WA, Lorga-Filho AM, Guimarães AJBA, Braga ALL, Oliveira AS, Sarabanda AVL, Pinto AYDN, Carmo AALD, Schmidt A, Costa ARD, Ianni BM, Markman Filho B, Rochitte CE, Macêdo CT, Mady C, Chevillard C, Virgens CMBD, Castro CN, Britto CFPC, Pisani C, Rassi DDC, Sobral Filho DC, Almeida DR, Bocchi EA, Mesquita ET, Mendes FSNS, Gondim FTP, Silva GMSD, Peixoto GL, Lima GG, Veloso HH, Moreira HT, Lopes HB, Pinto IMF, Ferreira JMBB, Nunes JPS, Barreto-Filho JAS, Saraiva JFK, Lannes-Vieira J, Oliveira JLM, Armaganijan LV, Martins LC, Sangenis LHC, Barbosa MPT, Almeida-Santos MA, Simões MV, Yasuda MAS, Moreira MDCV, Higuchi ML, Monteiro MRCC, Mediano MFF, Lima MM, Oliveira MT, Romano MMD, Araujo NNSL, Medeiros PTJ, Alves RV, Teixeira RA, Pedrosa RC, Aras Junior R, Torres RM, Povoa RMDS, Rassi SG, Alves SMM, Tavares SBDN, Palmeira SL, Silva Júnior TLD, Rodrigues TDR, Madrini Junior V, Brant VMDC, Dutra WO, Dias … See abstract for full author list ➔ Marin-Neto JA, et al. Arq Bras Cardiol. 2023 Jun 26;120(6):e20230269. doi: 10.36660/abc.20230269. Arq Bras Cardiol. 2023. PMID: 37377258 Free PMC article. English, Portuguese. No abstract available.

References

    1. Smith SC Jr., Collins A, Ferrari R et al (2012) Our time: a call to save preventable death from cardiovascular disease (heart disease and stroke). Circulation 126(23):2769–2775. https://doi.org/10.1161/CIR.0b013e318267e99f - DOI - PubMed
    1. Roth GA, Huffman MD, Moran AE et al (2015) Global and regional patterns in cardiovascular mortality from 1990 to 2013. Circulation 132(17):1667–1678. https://doi.org/10.1161/circulationaha.114.008720 - DOI - PubMed
    1. Odone A, McKee C, McKee M (2018) The impact of migration on cardiovascular diseases. Int J Cardiol 254:356–361. https://doi.org/10.1016/j.ijcard.2017.11.084 - DOI - PubMed
    1. Pavli A, Maltezou H (2017) Health problems of newly arrived migrants and refugees in Europe. J Travel Med. https://doi.org/10.1093/jtm/tax016 - DOI - PubMed
    1. Watkins DA, Johnson CO, Colquhoun SM et al (2017) Global, regional, and national burden of rheumatic heart disease, 1990–2015. N Engl J Med 377(8):713–722. https://doi.org/10.1056/NEJMoa1603693 - DOI - PubMed

LinkOut - more resources