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. 2021 Jan 28;16(1):e0246024.
doi: 10.1371/journal.pone.0246024. eCollection 2021.

Prevalence of Escherichia coli O157:H7 and associated factors in under-five children in Eastern Ethiopia

Dawit Kassaye Getaneh  1 , Lemessa Oljira Hordofa  2 , Desalegn Admassu Ayana  2 , Tesfaye Sisay Tessema  3 , Lemma Demissie Regassa  2
Affiliations

Prevalence of Escherichia coli O157:H7 and associated factors in under-five children in Eastern Ethiopia

Dawit Kassaye Getaneh et al. PLoS One. .

Abstract

Background: Escherichia coli O157:H7 (E. coli O157:H7) is one of the most potent zoonotic pathogens that causes mild diarrhea and leads to hemolytic uremic syndrome or death. This study was aimed to assess the prevalence and determinants of E. coli O157:H7 related to diarrhea among under-five children with acute diarrhea.

Methods: A cross-sectional study design was carried out in 2018 on 378 under-five-year children recruited randomly from hospitals in Eastern Ethiopia. Stool specimens were collected and processed using enrichment, differential and selective medium. Among isolates, E. coli O157:H7 was confirmed using latex test (Oxoid, Basingstoke, Hants, England). Factors associated with E. coli O157:H7 infection were identified using binary and multivariable logistic regression. Associations were reported by odds ratio with 95% confidence interval.

Results: The prevalence of E. coli O157:H7 related diarrhea was 15.3% (95%CI: 11.8-19.5). The E. coli O157:H7 infection was positively associated with rural residence (AOR;3.75, 95%CI:1.26-11.20), consumption of undercooked meat (AOR;3.95, 95%CI: 1.23-12.67), raw vegetables and/or fruit juice (AOR;3.37, 95%CI:1.32-8.62), presence of bloody diarrhea (AOR;4.42, 95% CI:1.78-10.94), number of under-five children in a household (AOR;7.16, 95%CI: 2.90-17.70), presence of person with diarrhea in a household (AOR;4.22, 95% CI: 1.84-12.69), owning domestic animal (AOR;3.87, 95% CI: 1.48-10.12) and uneducated mother (AOR;3.14, 95%CI: 1.05-9.42).

Conclusion: The Prevalence of E. coli O157:H7 related diarrhea among under-five children is relatively high in Eastern Ethiopia. The E. coli infection was associated with sanitation and hygiene in a household. Thus, education focused on food cooking and handling, child care, and household sanitation associated with animal manure in rural resident children are helpful in.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Schematic representation of the sampling procedure for selecting the study population from hospitals, Eastern Ethiopia, 2018.
Fig 2
Fig 2. Prevalence of E. coli O157:H7 related diarrhea among under five aged children from Public Hospitals of Eastern Ethiopia, 2018.
See this image and copyright information in PMC

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