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. 2021 Apr;30(4):630-640.
doi: 10.1177/0961203320988586. Epub 2021 Jan 28.

A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group

José A Gómez-Puerta  1 , Guillermo J Pons-Estel  2 , Rosana Quintana  2 , Romina Nieto  2 , Rosa M Serrano Morales  2 , Guillermina B Harvey  3 , Daniel Wojdyla  4 , Marina Scolnik  5 , Carmen Funes Soaje  6 , Paula Alba Moreyra  7 , Elisa Novatti  8 , Fernando Arizpe  9 , Guillermo A Berbotto  10 , Luciana González Lucero  11 , Sabrina Porta  12 , Nicolás Pérez  13 , Anabella M Rodriguez  14 , Simone Appenzeller  15 , Ana Carolina de Oliveira E Silva Montadon  16 , Odirlei Andre Monticielo  17 , Fernando S Cavalcanti  18 , Francinne Machado Ribeiro  19 , Eduardo F Borba  20 , Edgard Torres Dos Reis-Neto  21 , Oscar Neira  22 , José Miguel Chahuán  23 , Milena Mimica  24 , Gustavo Aroca Martínez  25   26 , Gabriel J Tobón  27 , Gloria Vásquez  28 , Gerardo Quintana-Lopez  29   30   31 , Mario J Moreno Alvarez  32 , Miguel Ángel Saavedra  33 , Mario Pérez Cristobal  34 , Hilda Fragoso-Loyo  35 , Luis M Amezcua-Guerra  36 , Yelitza C González-Bello  37 , Carlos Abud-Mendoza  38 , Jorge A Esquivel-Valerio  39 , Margarita Duarte  40 , Isabel Acosta Colman  41 , Claudia Mora-Trujillo  42 , Cristina Reátegui-Sokolova  43 , Armando A Calvo Quiroz  44 , Roberto Muñoz-Louis  45 , Ernesto Cairoli  46   47 , Iliana Rosas  48 , Martín Rebella  49 , Mario H Cardiel  50 , Ignacio García de la Torre  51 , Luis J Catoggio  5 , Graciela S Alarcón  52   53 , Bernardo A Pons-Estel  2 ; Gladel CO-authors
Affiliations

A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group

José A Gómez-Puerta et al. Lupus. 2021 Apr.

Abstract

Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of "Lupus Investigators" in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.

Keywords: Latin American; Lupus; biomarkers; lupus nephritis; multiethnic.

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Conflict of interest statement

Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship and/or publication of this article: Serological biomarkers will be carried out centrally by INOVA/Werfen laboratories. Janssen Pharmaceutical Companies of Johnson & Johnson is planned to provide logistic and financial support for transcriptome studies. Neither Inova laboratories nor Janssen Pharmaceutical Companies have participated or influenced the development of the project, nor do they have access to the information collected in the database.

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