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. 2021 Jan 28;21(1):40.
doi: 10.1186/s12876-021-01611-0.

Efficacy of a novel hemostatic adhesive powder in patients with upper gastrointestinal tumor bleeding

Jongbeom Shin  1 , Boram Cha  1 , Jin-Seok Park  2 , Weonjin Ko  1 , Kye Sook Kwon  1 , Jin-Woo Lee  1 , Hyung Kil Kim  1 , Yong Woon Shin  1
Affiliations

Efficacy of a novel hemostatic adhesive powder in patients with upper gastrointestinal tumor bleeding

Jongbeom Shin et al. BMC Gastroenterol. .

Abstract

Background: Gastrointestinal tumor bleeding remains a clinical challenge because it is difficult to treat with conventional endoscopic hemostatic options. Recently, an endoscopic hemostatic powder (UI-EWD) was developed and reported to provide effective control of upper gastrointestinal bleeding. The aim of current study was to evaluate the feasibility and efficacy of this novel hemostatic powder in tumor bleeding.

Methods: A total of 41 consecutive patients with upper gastrointestinal tumor bleeding were included. UI-EWD was applied in all patients as an auxiliary hemostatic method as a salvage therapy or monotherapy during endoscopic treatment. Hemostasis success rates, adverse event related to UI-EWD, and rates of re-bleeding were evaluated.

Results: In all cases, UI-EWD application was successful at tumor bleeding sites. Immediate hemostasis occurred in 40/41 (97.5%) patients, and re-bleeding within 28 days occurred in 10 of 40 (22.5%) patients that achieved initial hemostasis. The success rate of immediate hemostasis for UI-EWD monotherapy was 100% (23/23). The re-bleeding rate at 28 days after UI-EWD monotherapy was 26.1% (6/23). No adverse events associated with UI-EWD application were encountered.

Conclusions: The success rate of UI-EWD for immediate hemostasis in cases of GI tumor bleeding was excellent and UI-EWD produced promising results with respect to the prevention of re-bleeding. Based on these results, we suggest that UI-EWD be considered an effective salvage therapy or even monotherapy for GI tumor bleeding.

Keywords: Hemostatic powder; Salvage therapy; Tumor bleeding.

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Conflict of interest statement

All authors have no conflict of interest to declare in connection with this study.

Figures

Fig. 1
Fig. 1
Patient selection flowsheet
Fig. 2
Fig. 2
Images of UI-EWD (a) and the spraying device (b)
Fig. 3
Fig. 3
The endoscopic images of UI-EWD application for upper gastrointestinal tumor bleeding. a The patient had Forrest-Ib bleeding from gastric antrum due to advanced gastric cancer that could not be controlled by thermal therapy. b Application of UI-EWD at the bleeding site. c Five minutes after application, the UI-EWD was firmly attached at the tumor bleeding site without any sign of bleeding
Fig. 4
Fig. 4
Overall re-bleeding rates at 28 (a) and 180 days (b) after the endoscopic procedures
See this image and copyright information in PMC

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