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Comment
. 2021 Feb;99(2):311-313.
doi: 10.1016/j.kint.2020.10.034.

Results of the PROPINE randomized controlled trial: determining the ever-elusive target, the optimal plan for relapses of nephrotic syndrome in children

John D Mahan  1 , Mahmoud Kallash  2 , William E Smoyer  3
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Free article
Comment

Results of the PROPINE randomized controlled trial: determining the ever-elusive target, the optimal plan for relapses of nephrotic syndrome in children

John D Mahan et al. Kidney Int. 2021 Feb.
Free article

Abstract

Best treatments for initial presentation and relapses in children with nephrotic syndrome (NS) are still to be defined. The PROPINE study, published in this issue of Kidney International, demonstrates for relapse of childhood NS, the non-inferiority of a short taper (over 36 days) after remission with steroids. This study reinforces the need for more well-designed studies and the incorporation of predictive biomarkers, genetic studies, and other details to personalize treatment for each child with idiopathic NS.

Keywords: glomerular disease; nephrotic syndrome; pediatric nephrology.

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