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Review
. 2021 Sep;16(9):1730-1739.
doi: 10.4103/1673-5374.306066.

Promising drug targets and associated therapeutic interventions in Parkinson's disease

Sachchida Nand Rai  1 , Payal Singh  2 , Ritu Varshney  3 , Vivek K Chaturvedi  1 , Emanuel Vamanu  4 , M P Singh  1 , Brijesh Kumar Singh  5
Affiliations
Review

Promising drug targets and associated therapeutic interventions in Parkinson's disease

Sachchida Nand Rai et al. Neural Regen Res. 2021 Sep.

Abstract

Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the availability of symptomatic treatments, response towards the health of PD patients remains scarce. To fulfil the medical needs of the PD patients, an efficacious and etiological treatment is required. In this review, we have compiled the information covering limitations of current therapeutic options in PD, novel drug targets for PD, and finally, the role of some critical beneficial natural products to control the progression of PD.

Keywords: Parkinson’s disease; dopamine; epigenetics; gene therapies; glutamate receptor; levodopa; molecular chaperones; monoamine oxidase B; mucuna alpha-synuclein; striatum; substantia nigra.

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Conflict of interest statement

None

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