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. 2021 Sep;16(9):1801-1802.
doi: 10.4103/1673-5374.306084.

Microglial exosomes in retinal neuroinflammation: focus in glaucoma

Inês Dinis Aires  1 , Ana Raquel Santiago  2
Affiliations

Microglial exosomes in retinal neuroinflammation: focus in glaucoma

Inês Dinis Aires et al. Neural Regen Res. 2021 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

None

Figures

Figure 1
Figure 1
Schematic representation of the effects of exosomes derived from microglia exposed to elevated pressure on naïve microglia and neuronal cells. Exosomes released by microglia exposed to elevated pressure (EHP) amplify the inflammatory response, enhancing microglia reactivity and leading to retinal degeneration. IL-1β: Interleukin-1β; iNOS: inducible nitric oxide synthase; TNF: tumor necrosis factor; TSPO: translocator protein.
See this image and copyright information in PMC

References

    1. Aires ID, Ambrósio AF, Santiago AR. Modeling human glaucoma: lessons from the in vitro models. Ophthalmic Res. 2017;57:77–86. - PubMed
    1. Aires ID, Boia R, Rodrigues-Neves AC, Madeira MH, Marques C, Ambrósio AF, Santiago AR. Blockade of microglial adenosine A2A receptor suppresses elevated pressure-induced inflammation, oxidative stress, and cell death in retinal cells. Glia. 2019;67:896–914. - PMC - PubMed
    1. Aires ID, Ribeiro-Rodrigues T, Boia R, Catarino S, Girão H, Ambrósio AF, Santiago AR. Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells. Glia. 2020;68:2705–2724. - PubMed
    1. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015;18:1584–1593. - PMC - PubMed
    1. Bian B, Zhao C, He X, Gong Y, Ren C, Ge L, Zeng Y, Li Q, Chen M, Weng C, He J, Fang Y, Xu H, Yin ZQ. Exosomes derived from neural progenitor cells preserve photoreceptors during retinal degeneration by inactivating microglia. J Extracell Vesicles. 2020;9:1748931. - PMC - PubMed