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Comment
. 2021 Apr;18(4):219-220.
doi: 10.1038/s41575-021-00417-5.

A single-cell view of biliary atresia

Abigail E Russi  1 , Jorge A Bezerra  2   3   4
Affiliations
Comment

A single-cell view of biliary atresia

Abigail E Russi et al. Nat Rev Gastroenterol Hepatol. 2021 Apr.

Abstract

A new study elevates our understanding of how the immune system regulates the pathogenesis of biliary atresia through a powerful single-cell approach. Cell-specific transcriptome analyses indicate key roles for macrophages, T cells and B cells in hepatobiliary injury of affected infants.

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Conflict of interest statement

Competing interests

The authors declare no competing interests.

Comment on

  • Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia.
    Wang J, Xu Y, Chen Z, Liang J, Lin Z, Liang H, Xu Y, Wu Q, Guo X, Nie J, Lu B, Huang B, Xian H, Wang X, Wu Q, Zeng J, Chai C, Zhang M, Lin Y, Zhang L, Zhao S, Tong Y, Zeng L, Gu X, Chen ZG, Yi S, Zhang T, Delfouneso D, Zhang Y, Nutt SL, Lew AM, Lu L, Bai F, Xia H, Wen Z, Zhang Y. Wang J, et al. Cell. 2020 Dec 23;183(7):1867-1883.e26. doi: 10.1016/j.cell.2020.10.048. Epub 2020 Nov 27. Cell. 2020. PMID: 33248023

References

    1. Bezerra JA et al. Biliary atresia: clinical and research challenges for the twenty-first century. Hepatology 68, 1163–1173 (2018). - PMC - PubMed
    1. Bezerra JA et al. Genetic induction of proinflammatory immunity in children with biliary atresia. Lancet 360, 1653–1659 (2002). - PubMed
    1. Shivakumar P et al. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J. Clin. Invest. 114, 322–329 (2004). - PMC - PubMed
    1. Asai A, Miethke A & Bezerra JA Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes. Nat. Rev. Gastroenterol. Hepatol. 12, 342–352 (2015). - PMC - PubMed
    1. Bednarek J et al. Cytokine-producingBcells promote immune-mediated bile duct injury in murine biliary atresia. Hepatology 68, 1890–1904 (2018). - PMC - PubMed

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