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Review
. 2021 Jan 7;14(1):100499.
doi: 10.1016/j.waojou.2020.100499. eCollection 2021 Jan.

Air pollution and indoor settings

Nelson Augusto Rosário Filho  1 , Marilyn Urrutia-Pereira  2 , Gennaro D'Amato  3 , Lorenzo Cecchi  4 , Ignacio J Ansotegui  5 , Carmen Galán  6 , Anna Pomés  7 , Margarita Murrieta-Aguttes  8 , Luis Caraballo  9 , Philip Rouadi  10 , Herberto J Chong-Neto  11 , David B Peden  12
Affiliations
Review

Air pollution and indoor settings

Nelson Augusto Rosário Filho et al. World Allergy Organ J. .

Abstract

Indoor environments contribute significantly to total human exposure to air pollutants, as people spend most of their time indoors. Household air pollution (HAP) resulting from cooking with polluting ("dirty") fuels, which include coal, kerosene, and biomass (wood, charcoal, crop residues, and animal manure) is a global environmental health problem. Indoor pollutants are gases, particulates, toxins, and microorganisms among others, that can have an impact especially on the health of children and adults through a combination of different mechanisms on oxidative stress and gene activation, epigenetic, cellular, and immunological systems. Air pollution is a major risk factor and contributor to morbidity and mortality from major chronic diseases. Children are significantly affected by the impact of the environment due to biological immaturity, prenatal and postnatal lung development. Poor air quality has been related to an increased prevalence of clinical manifestations of allergic asthma and rhinitis. Health professionals should increase their role in managing the exposure of children and adults to air pollution with better methods of care, prevention, and collective action. Interventions to reduce household pollutants may promote health and can be achieved with education, community, and health professional involvement.

Keywords: AR, allergic rhinitis; Air pollutants; BAL, bronchoalveolar lavage; CO, carbon monoxide; CO2, carbon dioxide; COPD, chronic obstructive pulmonary disease; DEPs, diesel exhaust particles; Environmental pollution; FEV1, forced expiratory volume; FeNO, fractional exhaled nitric oxide; GM-CSF, granulocyte and macrophage growth stimulating factor; GST, glutathione S-transferase; HAP, household air pollution; HEPA, High Efficiency Particulate Arrestance; ILC2, innate lymphoid cells; Indoor air pollution; NCD, non-communicable disease; NO, nitric oxide; NO2, nitrogen dioxide; O3, ozone; PAH, polycyclic aromatic hydrocarbons; PM, particulate matter; PMNs, polymorphonuclear leukocytes; Pollution; SO2, sulfur dioxide; TRAP, Traffic-related air pollution; TSLP, thymic stromal lymphopoietin; VOCs, volatile organic compounds.

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Conflict of interest statement

Dr. Ansotegui reports personal fees Mundipharma, Roxall, Sanofi, MSD, Faes Farma, Hikma, UCB, Astra Zeneca, Stallergenes, Abbott, and Bial, outside the submitted work. Dr. Murrieta-Aguttes reports personal fees from Sanofi, outside the submitted work, and she is an employee of Sanofi-Aventis Group, Consumer Healthcare Division, France. Dr. Pomés reports grants from NIH/NIAID, during the conduct of the study; other from Indoor Biotechnologies, Inc., outside the submitted work. Dr. Caraballo, Dr. Cecchi, Dr. Chong Neto, Dr. D'Amato, Dr. Galán, Dr. Peden, Dr. Rosário, Dr. Rouadi, and Dr. Urrutia Pereira have nothing to disclose.

Figures

Fig. 1
Fig. 1
Indoor air pollution – sources and Geo-epidemiological correlates. Indoor air and outdoor air share basically the same pollutants but in different proportions. In densely populated areas using biomass, indoor air pollutants may become outdoor—the so called “neighbourhood” pollution effect.
See this image and copyright information in PMC

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