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Review
. 2021 Jan 4:19:624-631.
doi: 10.1016/j.csbj.2021.01.001. eCollection 2021.

Skin microbiome transplantation and manipulation: Current state of the art

Chris Callewaert  1   2 , Nastassia Knödlseder  3 , Ante Karoglan  4 , Marc Güell  3 , Bernhard Paetzold  5
Affiliations
Review

Skin microbiome transplantation and manipulation: Current state of the art

Chris Callewaert et al. Comput Struct Biotechnol J. .

Abstract

Many skin conditions are associated with an imbalance in the skin microbiome. In recent years, the skin microbiome has become a hot topic, for both therapeutic and cosmetic purposes. The possibility of manipulating the human skin microbiome to address skin conditions has opened exciting new paths for therapy. Here we review the skin microbiome manipulation strategies, ranging from skin microbiome transplantation, over skin bacteriotherapy to the use of prebiotics, probiotics and postbiotics. We summarize all efforts undertaken to exchange, manipulate, transplant or selectively apply the skin microbiome to date. Multiple microbial groups have been targeted, since they have been proven to be beneficial for skin health. We focus on the most common skin disorders and their associated skin microbiome dysbiosis and we review the existing scientific data and clinical trials undertaken to combat these skin conditions. The skin microbiome represents a novel platform for therapy. Transplantation of a complete microbiome or application of single strains has demonstrated beneficial therapeutic application.

Keywords: Microbiome manipulation; Microbiome transplantation; Skin microbiome; Skin microbiome modulation.

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Conflict of interest statement

All authors of this review previously published in this field. MG and BP are founders of S-Biomedic N.V. a company active in the skin microbiome field.

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