Heterochronic blood exchange attenuates age-related neuroinflammation and confers cognitive benefits: do microvascular protective effects play a role?

Derek M Huffman¹, Anna Csiszar², Zoltan Ungvari^{2

3}

Affiliations

¹ Department of Molecular Pharmacology and Medicine, The Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer Bldg., Rm. 236, Bronx, NY, 10461, USA. derek.huffman@einsteinmed.org.
² Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
³ International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.

Editorial

Derek M Huffman et al. Geroscience. 2021 Feb.

. 2021 Feb;43(1):111-113.

doi: 10.1007/s11357-021-00324-2. Epub 2021 Jan 28.

Derek M Huffman¹, Anna Csiszar², Zoltan Ungvari^{2

3}

¹ Department of Molecular Pharmacology and Medicine, The Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer Bldg., Rm. 236, Bronx, NY, 10461, USA. derek.huffman@einsteinmed.org.
² Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
³ International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.

No abstract available

References

1. Conboy MJ, Conboy IM, Rando TA. Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity. Aging Cell. 2013;12(3):525–530. doi: 10.1111/acel.12065. - DOI - PMC - PubMed
1. Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature. 2011;477(7362):90–94. doi: 10.1038/nature10357. - DOI - PMC - PubMed
1. Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;433(7027):760–764. doi: 10.1038/nature03260. - DOI - PubMed
1. Yousefzadeh MJ, Wilkinson JE, Hughes B, Gadela N, Ladiges WC, Vo N, Niedernhofer LJ, Huffman DM, Robbins PD. Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues. Geroscience. 2020;42(3):951–961. doi: 10.1007/s11357-020-00185-1. - DOI - PMC - PubMed
1. Mehdipour M. Mehdipour T. Wong N, Liu C, Chen CC, et al. Plasma dilution improves cognition and attenuates neuroinflammation in old mice. Geroscience: Skinner CM; 2020. - PMC - PubMed