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. 2021 Mar 18;137(11):1553-1555.
doi: 10.1182/blood.2020006919.

Dietary iron restriction improves markers of disease severity in murine sickle cell anemia

Nermi L Parrow  1 , Pierre-Christian Violet  2 , Nisha Ajit George  1 , Faris Ali  1 , Shivam Bhanvadia  1 , Ryan Wong  1 , John F Tisdale  3 , Courtney Fitzhugh  3 , Mark Levine  2 , Swee Lay Thein  4 , Robert E Fleming  1   5
Affiliations

Dietary iron restriction improves markers of disease severity in murine sickle cell anemia

Nermi L Parrow et al. Blood. .

Abstract

There is a Blood Commentary on this article in this issue.

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Conflict of interest statement

Conflict-of-interest disclosure: R.E.F. is a member of the Scientific Advisory Boards of Protagonist Therapeutics and Silence Therapeutics and receives research funding from Ultragenyx. The remaining authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
Iron restriction improves hematological parameters in Townes sickle mice. (A-E) Townes HbSS and trait HbAS mice weaned and maintained on either a 48- or 20-ppm iron diet for 8-10 weeks. Then serum iron (A), mean corpuscular hemoglobin concentrations (B), red blood cell counts (C), hematocrit (D), hemoglobin concentration (E), and reticulocyte count (F) were measured; n = 6-13 mice per group. Data represented as means ± standard error of the mean. *P < .05; ***P < .005; ****P < .001. ns, nonsignificant.
Figure 2.
Figure 2.
Iron restriction attenuates hypoxia induced sickling. (A) Point of sickling of RBCs from Townes HbSS mice fed a 20- or 48-ppm iron diet. (B-D) Difference in EI (B), EI min (C), and EI max (D) in HbSS mice fed a 20- or 48-ppm iron diet. For panel A, n = 9-13 mice per group. For panels B-D, n = 10-13 mice per group. Data represented as means ± standard error of the mean. *P < .05; ****P < .001. ns, nonsignificant.
See this image and copyright information in PMC

Comment in

  • Less (Fe) is more (Hb) in SCA.
    Brugnara C. Brugnara C. Blood. 2021 Mar 18;137(11):1446-1447. doi: 10.1182/blood.2020010131. Blood. 2021. PMID: 33734335 No abstract available.

References

    1. Pauling L, Itano HA, Singer SJ, Wells IC. Sickle cell anemia, a molecular disease. Science. 1949;110(2865):543-548. - PubMed
    1. Hofrichter J, Ross PD, Eaton WA. Kinetics and mechanism of deoxyhemoglobin S gelation: a new approach to understanding sickle cell disease. Proc Natl Acad Sci U S A. 1974;71(12):4864-4868. - PMC - PubMed
    1. Castro O, Poillon WN, Finke H, Massac E. Improvement of sickle cell anemia by iron-limited erythropoiesis. Am J Hematol. 1994;47(2):74-81. - PubMed
    1. Rao KR, Patel AR, Honig GR, Vida LN, McGinnis PR. Iron deficiency and sickle cell anemia. Arch Intern Med. 1983;143(5):1030-1032. - PubMed
    1. Castro O, Medina A, Gaskin P, Kato GJ, Gordeuk VR. Iron deficiency decreases hemolysis in sickle cell anemia. Rev Bras Hematol Hemoter. 2009;31(1):51-53.

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