Impacts of gut microbiota on gestational diabetes mellitus: a comprehensive review

doi:10.1007/s00394-021-02483-6

Review

. 2021 Aug;60(5):2343-2360.

doi: 10.1007/s00394-021-02483-6. Epub 2021 Jan 29.

Impacts of gut microbiota on gestational diabetes mellitus: a comprehensive review

Lingling Huang^{1

2}, Chanisa Thonusin^{1

2

3}, Nipon Chattipakorn^{1

2

3}, Siriporn C Chattipakorn^{4

5

6}

Affiliations

¹ Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
² Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, 50200, Thailand.
³ Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
⁴ Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. siriporn.c@cmu.ac.th.
⁵ Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, 50200, Thailand. siriporn.c@cmu.ac.th.
⁶ Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. siriporn.c@cmu.ac.th.

PMID: 33512587
DOI: 10.1007/s00394-021-02483-6

Review

Impacts of gut microbiota on gestational diabetes mellitus: a comprehensive review

Lingling Huang et al. Eur J Nutr. 2021 Aug.

. 2021 Aug;60(5):2343-2360.

doi: 10.1007/s00394-021-02483-6. Epub 2021 Jan 29.

Authors

Lingling Huang^{1

2}, Chanisa Thonusin^{1

2

3}, Nipon Chattipakorn^{1

2

3}, Siriporn C Chattipakorn^{4

5

6}

Affiliations

¹ Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
² Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, 50200, Thailand.
³ Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
⁴ Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. siriporn.c@cmu.ac.th.
⁵ Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, 50200, Thailand. siriporn.c@cmu.ac.th.
⁶ Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. siriporn.c@cmu.ac.th.

PMID: 33512587
DOI: 10.1007/s00394-021-02483-6

Abstract

Background: Gestational diabetes mellitus (GDM) is a condition that seriously threatens mother and child health. The incidence of GDM has increased worldwide in the past decades. In addition, the complications of GDM such as type 2 diabetes (T2DM) and neonatal malformations could negatively affect the living quality of mothers and their children.

Aim: It has been widely known that the imbalance of gut microbiota or called 'gut dysbiosis' plays a key role in the development of insulin resistance and chronic low-grade inflammation in T2DM patients. However, the impacts of gut microbiota on GDM remain controversial. Here, we aim to comprehensively review the alterations of gut microbiota in GDM mothers and their offspring.

Results: The alterations of Firmicutes/Bacteroidetes (F/B) ratio, short-chain fatty acid (SCFA)-producing bacteria, bacteria with probiotics properties and gram-negative lipopolysaccharide (LPS)-producing bacteria play a vital role in the development of GDM. The beneficial roles of gut microbiota modification (probiotics, synbiotics and lifestyle modification) as a treatment of GDM were found in some, but not all studies.

Conclusion: In the near future, gut microbiota modification may be considered as one of the standard treatments for GDM. Moreover, further studies regarding the specific gut microbiota that are associated with the early development of GDM are required. This may contribute to the novel diagnostic markers for early stages of GDM.

Keywords: Gestational diabetes mellitus; Gut dysbiosis; Gut microbiota; Insulin resistance; Probiotics; Synbiotics.

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Gut microbiota diversity in middle-aged and elderly patients with end-stage diabetic kidney disease.
Chen R, Zhu D, Yang R, Wu Z, Xu N, Chen F, Zhang S, Chen H, Li M, Hou K. Chen R, et al. Ann Transl Med. 2022 Jul;10(13):750. doi: 10.21037/atm-22-2926. Ann Transl Med. 2022. PMID: 35957707 Free PMC article.
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References

1. Weinert LS (2010) International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy: comment to the International Association of Diabetes and Pregnancy Study Groups Consensus Panel. Diabetes Care 33(7):e97–e97. https://doi.org/10.2337/dc10-0544 - DOI - PubMed
1. McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P (2019) Gestational diabetes mellitus. Nat Rev Dis Primers 5(1):47. https://doi.org/10.1038/s41572-019-0098-8 - DOI - PubMed
1. Daly B, Toulis KA, Thomas N, Gokhale K, Martin J, Webber J, Keerthy D, Jolly K, Saravanan P, Nirantharakumar K (2018) Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: a population-based cohort study. PLoS Med 15(1):e1002488. https://doi.org/10.1371/journal.pmed.1002488 - DOI - PubMed - PMC
1. Li L-J, Tan KH, Aris IM, Man REK, Gan ATL, Chong YS, Saw SM, Gluckman P, Wong TY, Lamoureux E (2018) Retinal vasculature and 5-year metabolic syndrome among women with gestational diabetes mellitus. Metabolism 83:216–224. https://doi.org/10.1016/j.metabol.2017.10.004 - DOI - PubMed
1. Grandi SM, Filion KB, Yoon S, Ayele HT, Doyle CM, Hutcheon JA, Smith GN, Gore GC, Ray JG, Nerenberg K, Platt RW (2019) Cardiovascular disease-related morbidity and mortality in women with a history of pregnancy complications. Circulation 139(8):1069–1079. https://doi.org/10.1161/circulationaha.118.036748 - DOI - PubMed

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[1] Weinert LS (2010) International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy: comment to the International Association of Diabetes and Pregnancy Study Groups Consensus Panel. Diabetes Care 33(7):e97–e97. https://doi.org/10.2337/dc10-0544 - DOI - PubMed

[2] Weinert LS (2010) International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy: comment to the International Association of Diabetes and Pregnancy Study Groups Consensus Panel. Diabetes Care 33(7):e97–e97. https://doi.org/10.2337/dc10-0544 - DOI - PubMed

[3] McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P (2019) Gestational diabetes mellitus. Nat Rev Dis Primers 5(1):47. https://doi.org/10.1038/s41572-019-0098-8 - DOI - PubMed

[4] McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P (2019) Gestational diabetes mellitus. Nat Rev Dis Primers 5(1):47. https://doi.org/10.1038/s41572-019-0098-8 - DOI - PubMed

[5] Daly B, Toulis KA, Thomas N, Gokhale K, Martin J, Webber J, Keerthy D, Jolly K, Saravanan P, Nirantharakumar K (2018) Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: a population-based cohort study. PLoS Med 15(1):e1002488. https://doi.org/10.1371/journal.pmed.1002488 - DOI - PubMed - PMC

[6] Daly B, Toulis KA, Thomas N, Gokhale K, Martin J, Webber J, Keerthy D, Jolly K, Saravanan P, Nirantharakumar K (2018) Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: a population-based cohort study. PLoS Med 15(1):e1002488. https://doi.org/10.1371/journal.pmed.1002488 - DOI - PubMed - PMC

[7] Li L-J, Tan KH, Aris IM, Man REK, Gan ATL, Chong YS, Saw SM, Gluckman P, Wong TY, Lamoureux E (2018) Retinal vasculature and 5-year metabolic syndrome among women with gestational diabetes mellitus. Metabolism 83:216–224. https://doi.org/10.1016/j.metabol.2017.10.004 - DOI - PubMed

[8] Li L-J, Tan KH, Aris IM, Man REK, Gan ATL, Chong YS, Saw SM, Gluckman P, Wong TY, Lamoureux E (2018) Retinal vasculature and 5-year metabolic syndrome among women with gestational diabetes mellitus. Metabolism 83:216–224. https://doi.org/10.1016/j.metabol.2017.10.004 - DOI - PubMed

[9] Grandi SM, Filion KB, Yoon S, Ayele HT, Doyle CM, Hutcheon JA, Smith GN, Gore GC, Ray JG, Nerenberg K, Platt RW (2019) Cardiovascular disease-related morbidity and mortality in women with a history of pregnancy complications. Circulation 139(8):1069–1079. https://doi.org/10.1161/circulationaha.118.036748 - DOI - PubMed

[10] Grandi SM, Filion KB, Yoon S, Ayele HT, Doyle CM, Hutcheon JA, Smith GN, Gore GC, Ray JG, Nerenberg K, Platt RW (2019) Cardiovascular disease-related morbidity and mortality in women with a history of pregnancy complications. Circulation 139(8):1069–1079. https://doi.org/10.1161/circulationaha.118.036748 - DOI - PubMed

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Impacts of gut microbiota on gestational diabetes mellitus: a comprehensive review

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Impacts of gut microbiota on gestational diabetes mellitus: a comprehensive review

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