Oral Human Papillomavirus Infection in Children during the First 6 Years of Life, Finland

Abstract

Human papillomavirus (HPV) infections are found in children, but transmission modes and outcomes are incompletely understood. We evaluated oral samples from 331 children in Finland who participated in the Finnish Family HPV Study from birth during 9 follow-up visits (mean time 51.9 months). We tested samples for 24 HPV genotypes. Oral HPV prevalence for children varied from 8.7% (at a 36-month visit) to 22.8% (at birth), and 18 HPV genotypes were identified. HPV16 was the most prevalent type to persist, followed by HPV18, HPV33, and HPV6. Persistent, oral, high-risk HPV infection for children was associated with oral HPV carriage of the mother at birth and seroconversion of the mother to high-risk HPV during follow-up (odds ratio 1.60-1.92, 95% CI 1.02-2.74). Children acquire their first oral HPV infection at an early age. The HPV status of the mother has a major impact on the outcome of oral HPV persistence for her offspring.

Keywords: Finland; HPV; children; human papillomavirus; oral cavity; oral infection; sexually transmitted infections; viruses.

Figure

Oral HPV infection in 324 children in the Finnish Family HPV Study during the first 6 years of life. Each visit shows the number of children who participated in the specific follow-up, timeline of the visit, and samples obtained at each visit. HPV, human papillomavirus.