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Comment
. 2021 Apr 12;39(4):449-451.
doi: 10.1016/j.ccell.2021.01.014. Epub 2021 Jan 28.

Subversion of calreticulin exposure as a strategy of immune escape

Guido Kroemer  1 , Laurence Zitvogel  2
Affiliations
Free article
Comment

Subversion of calreticulin exposure as a strategy of immune escape

Guido Kroemer et al. Cancer Cell. .
Free article

Abstract

In this issue, Lin et al. report that, in malignant cells, stanniocalcin-1 (STC1) prevents the cell surface exposure of the "eat me" signal calreticulin, thereby avoiding phagocytosis by antigen-presenting cells. STC1 overexpression joins an arsenal of mechanisms through which tumor cells suppress calreticulin exposure and escape from immunosurveillance.

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Conflict of interest statement

Declaration of interests G.K. and L.Z. are listed as inventors on several patents (WO2008028968A2, WO2011131472A1, WO2012007783A1) dealing with calreticulin and cancer immunosurveillance.

Comment on

  • Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance.
    Lin H, Kryczek I, Li S, Green MD, Ali A, Hamasha R, Wei S, Vatan L, Szeliga W, Grove S, Li X, Li J, Wang W, Yan Y, Choi JE, Li G, Bian Y, Xu Y, Zhou J, Yu J, Xia H, Wang W, Alva A, Chinnaiyan AM, Cieslik M, Zou W. Lin H, et al. Cancer Cell. 2021 Apr 12;39(4):480-493.e6. doi: 10.1016/j.ccell.2020.12.023. Epub 2021 Jan 28. Cancer Cell. 2021. PMID: 33513345 Free PMC article.

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