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Comment
. 2021 Mar 8;39(3):301-303.
doi: 10.1016/j.ccell.2021.01.009. Epub 2021 Jan 28.

Neutrophils create a fertile soil for metastasis

Kevin Kos  1 , Karin E de Visser  2
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Neutrophils create a fertile soil for metastasis

Kevin Kos et al. Cancer Cell. .
Free article

Abstract

Neutrophils can facilitate the metastatic spread of cancer; however, how neutrophils are activated at metastatic sites remains poorly understood. In this issue, Xiao et al. demonstrate that the protease cathepsin C, secreted by breast cancer cells, triggers neutrophils to form neutrophil extracellular traps in the metastatic niche, thereby promoting lung metastasis.

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Conflict of interest statement

Declaration of Interests K.E.d.V. reports research funding from Roche and is consultant for Third Rock Ventures, outside the scope of this work.

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