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Review
. 2021 Apr 12;39(4):443-446.
doi: 10.1016/j.ccell.2021.01.010. Epub 2021 Jan 28.

Self-organization in cancer: Implications for histopathology, cancer cell biology, and metastasis

Senthil K Muthuswamy  1
Affiliations
Free article
Review

Self-organization in cancer: Implications for histopathology, cancer cell biology, and metastasis

Senthil K Muthuswamy. Cancer Cell. .
Free article

Abstract

Pathologists use histological features to classify tumors and assign site of origin for metastasis. How and why tumors organize the way they do and recreate their histological organization during metastasis is unknown. Here, I discuss the concept of "histostasis" conferring tumors a histological memory and hypothesize its implications for metastasis.

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Conflict of interest statement

Declaration of interests S.K.M. is a member of the Scientific Advisory Board for KAHR Medical and has a patent application pending for media used to grow organoids (US20170267977A1).

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