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Review
. 2021 Jan 27;11(2):166.
doi: 10.3390/biom11020166.

Galectin-3 and sST2 as Prognosticators for Heart Failure Requiring Extracorporeal Life Support: Jack n' Jill

Jianli Bi  1   2 , Vidu Garg  1   2   3   4 , Andrew R Yates  1   2   3
Affiliations
Review

Galectin-3 and sST2 as Prognosticators for Heart Failure Requiring Extracorporeal Life Support: Jack n' Jill

Jianli Bi et al. Biomolecules. .

Abstract

Extracorporeal life support provides perfusion for patients with heart failure to allow time for recovery, function as a bridge for patients to heart transplantation, or serve as destination therapy for long term mechanical device support. Several biomarkers have been employed in attempt to predict these outcomes, but it remains to be determined which are suitable to guide clinical practice relevant to extracorporeal life support. Galectin-3 and soluble suppression of tumorigenicity-2 (sST2) are two of the more promising candidates with the greatest supporting evidence. In this review, we address the similarities and differences between galectin-3 and sST2 for prognostic prediction in adults and children with heart failure requiring extracorporeal life support and highlight the significant lack of progress in pediatric biomarker discovery and utilization.

Keywords: ECMO; VAD; extracorporeal life support; galectin-3; heart failure; mechanical circulatory support; sST2.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic of possible mechanism of galectin 3 and sST2 in heart failure.
Figure 2
Figure 2
Comparison of sST2 and galectin-3 between adults and children undergoing VAD. Redrawn based upon data reported in [15]. (A) Significantly higher circulating level of sST2 in children than in adults at every time points; (B) No difference in the circulating level of galectin-3.
See this image and copyright information in PMC

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