Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jan;51(1):28-34.
doi: 10.1136/jnnp.51.1.28.

Quantitative objective assessment of peripheral nociceptive C fibre function

N Parkhouse  1 , P M Le Quesne
Affiliations

Quantitative objective assessment of peripheral nociceptive C fibre function

N Parkhouse et al. J Neurol Neurosurg Psychiatry. 1988 Jan.

Abstract

A technique is described for the quantitative assessment of peripheral nociceptive C fibre function by measurement of the axon reflex flare. Acetylcholine, introduced by electrophoresis, is used to stimulate a ring of nociceptive C fibre endings at the centre of which the increase in blood flow is measured with a laser Doppler flowmeter. This flare (neurogenic vasodilatation) has been compared with mechanically or chemically stimulated non-neurogenic cutaneous vasodilation. The flare is abolished by local anaesthetic and is absent in denervated skin. The flare has been measured on the sole of the foot of 96 healthy subjects; its size decreases with age in males, but not in females.

PubMed Disclaimer

References

    1. Acta Med Scand. 1957 Sep 20;158(5):315-25 - PubMed
    1. J Physiol. 1960 Mar;150:501-14 - PubMed
    1. J Neurol Neurosurg Psychiatry. 1985 Apr;48(4):354-60 - PubMed
    1. J Neurol Neurosurg Psychiatry. 1986 Jan;49(1):1-10 - PubMed
    1. J Pediatr. 1963 Nov;63:889-94 - PubMed

Publication types

LinkOut - more resources