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. 2021 Mar;57(3):106293.
doi: 10.1016/j.ijantimicag.2021.106293. Epub 2021 Jan 27.

Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals

R J Brüggemann  1 , D J A R Moes  2 , K P van Rhee  3 , N E van 't Veer  4 , B C P Koch  5 , M van Rossum  6 , A Vermeulen Windsant-van den Tweel  7 , M H E Reijers  8 , R R J van Kimmenade  9 , J C Rahamat-Langedoen  10 , T C D Rettig  11 , R van Raalte  12 , J van Paassen  13 , F N Polderman  14 , P D van der Linden  15 , T Frenzel  16 , Q de Mast  17 , D M Burger  18 , J Schouten  19 , F L van de Veerdonk  20 , P Pickkers  21 , R Ter Heine  22
Affiliations

Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals

R J Brüggemann et al. Int J Antimicrob Agents. 2021 Mar.
No abstract available

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Figures

Figure 1
Figure 1
Left panel: Total (free and protein-bound) concentration of chloroquine in μmol/L for every treatment day of chloroquine. Middle panel: metabolite desethylchloroquine in μmol/L. Right panel: sum of chloroquine and desethylchloroquine in μmol/L. Dashed line in left panel represents the IC90 from the study by Wang et al . All concentrations are shown irrespective of time of day.
See this image and copyright information in PMC

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