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Review
. 2021 Mar 10:331:503-514.
doi: 10.1016/j.jconrel.2021.01.035. Epub 2021 Jan 28.

Engineered drug delivery devices to address Global Health challenges

Ilin Sadeghi  1 , James Byrne  2 , Rameen Shakur  1 , Robert Langer  3
Affiliations
Review

Engineered drug delivery devices to address Global Health challenges

Ilin Sadeghi et al. J Control Release. .

Abstract

There is a dire need for innovative solutions to address global health needs. Polymeric systems have been shown to provide substantial benefit to all sectors of healthcare, especially for their ability to extend and control drug delivery. Herein, we review polymeric drug delivery devices for vaccines, tuberculosis, and contraception.

Keywords: Contraception; DNA/RNA delivery; Delivery of TB drugs; Drug delivery; Global health challenges; Materials science; Microneedles; Microparticles; Nanoparticles; Polymer science; Polymeric drug delivery; Surface-eroding polymers; Vaccine delivery; Vaccine development.

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Figures

Unlabelled Image
Graphical abstract
Fig. 1
Fig. 1
Application of materials sciences in global health challenges; created with BioRender.
Fig. 2
Fig. 2
Polymeric platforms for single-injection vaccine delivery; created with BioRender.
Fig. 3
Fig. 3
Polymeric particulates for intracellular delivery of antigen shown in blue. (A) PLGA NPs containing ammonium bicarbonate. (B) PMAASH hydrogel MC formed by LbL assembly. (C) Micellar NP formed by BCP self-assembly. (D) NP with crosslinked PPS core and polyhydroxylated surface; created with BioRender. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Fig. 4
Fig. 4
Gastric residential device for delivering anti-tuberculosis medications. (A) Placement of the device through a nasogastric tube. (B) Cartoon representation of the assembled device. (C) Radiographic evaluation of the device in the stomach over 28 days. (D) Method of sensing and retrieving the device from the stomach using a Hall effect sensor. Used with permission from reference [112].
See this image and copyright information in PMC

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