The potential of photodynamic therapy in current breast cancer treatment methodologies

Abstract

Photodynamic Therapy (PDT) has been known for over a hundred years, and currently gaining in acceptance as an alternative cancer treatment. Light delivery is still a difficult problem in deep cancer treatment with PDT. Only near-infrared light in the 700-1100 nm range can penetrate deeply into the tissue because most tissue chromophores, including oxyhemoglobin, deoxyhemoglobin, melanin and fat, poorly absorb in the near infrared window. The light sources used in PDT are lasers, arc lamps, light-emitting diodes and fluorescent lamps. PDT has been used for many different clinical applications. PDT may be excellent alternative in the treatment and diagnosis of breast cancer compared to the conventional surgery, chemotherapy and radiotherapy. The basic elements of PDT are an appropriate photosensitizer (PS), oxygen, and light. The effectiveness of photodynamic therapy depends on the induction of photocytotoxic reactions, which are the result of light activation of PS), pre-administered to the body. The condition for initiating PDT processes is light absorption by PS and subsequent localized generation of cytotoxic reactive oxygen species. This study is a review of empirical research aimed at improving the therapy and diagnosis of breast cancer using PDT based on the physicochemical differences in healthy and diseased tissues and the tissues undergoing treatment.

Keywords: Breast cancer; Photodynamic therapy; Photosensitizer.