Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2021 Jul;47(7):1651-1660.
doi: 10.1016/j.ejso.2021.01.011. Epub 2021 Jan 21.

One-year excess mortality and treatment in surgically treated patients with colorectal cancer: A EURECCA European comparison

Renu R Bahadoer  1 , Esther Bastiaannet  2 , Yvette H M Claassen  3 , Marianne van der Mark  4 , Elizabeth van Eycken  5 , Julie Verbeeck  6 , Marianne G Guren  7 , Hartwig Kørner  8 , Anna Martling  9 , Robert Johansson  10 , Cornelis J H van de Velde  11 , Jan Willem T Dekker  12
Affiliations
Observational Study

One-year excess mortality and treatment in surgically treated patients with colorectal cancer: A EURECCA European comparison

Renu R Bahadoer et al. Eur J Surg Oncol. 2021 Jul.

Abstract

Background: Mortality in the first postoperative year represents an accurate reflection of the perioperative risk after colorectal cancer surgery. This research compares one-year mortality after surgery divided into three age-categories (18-64, 65-74, ≥75 years), focusing on time trends and comparing treatment strategies.

Material: Population-based data of all patients diagnosed and treated surgically for stage I-III primary colorectal cancer from 2007 to 2016, were collected from Belgium, the Netherlands, Norway, and Sweden. Stratified for age-category and stage, treatment was evaluated, and 30-day, one-year and one-year excess mortality were calculated for colon and rectal cancer separately. Results were evaluated over two-year time periods.

Results: Data of 206,024 patients were analysed. Postoperative 30-day and one-year mortality reduced significantly over time in all countries and age-categories. Within the oldest age category, in 2015-2016, one-year excess mortality varied from 9% in Belgium to 4% in Sweden for colon cancer and, from 9% in Belgium to 3% in the other countries for rectal cancer. With increasing age, patients were less likely to receive additional therapy besides surgery. In Belgium, colon cancer patients were more often treated with adjuvant chemotherapy (p < 0.001). For neoadjuvant treatment of rectal cancer, patients in Belgium and Norway were mostly treated with chemoradiotherapy. In the Netherlands and Sweden, radiotherapy alone was preferred (p < 0.001).

Conclusions: Despite improvement over time in all countries and age-categories, substantial variation exists in one-year postoperative mortality. Differences in one-year excess postoperative mortality could be due to differences in treatment strategies, highlighting the consequences of under- and over-treatment on cancer survival.

Keywords: Colorectal neoplasms; Internationality; Mortality; Treatment; epidemiology.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paperRenu R. Bahadoer, Esther Bastiaannet, Yyvette H.M. Claassen, Marianne van der Mark, Elizabeth van Eycken, Julie Verbeeck, Marianne G. Guren, Hartwig Kørner, Anna Martling, Robert Johansson, Cornelis J.H van de Velde, Jan W.T. Dekker

Publication types

LinkOut - more resources