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. 1988 Jan 20;199(2):389-92.
doi: 10.1016/0022-2836(88)90323-3.

Structure of tumour necrosis factor by X-ray solution scattering and preliminary studies by single crystal X-ray diffraction

A Lewit-Bentley  1 , R Fourme, R Kahn, T Prangé, P Vachette, J Tavernier, G Hauquier, W Niers
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Structure of tumour necrosis factor by X-ray solution scattering and preliminary studies by single crystal X-ray diffraction

A Lewit-Bentley et al. J Mol Biol. .

Abstract

The structure of tumour necrosis factor has been investigated by X-ray small-angle scattering and X-ray diffraction using synchrotron radiation. The overall radius of gyration is 25.5 A. A plausible model accounting for the scattering curves consists of an elongated trimer with an axial ratio of 3 to 4 and a maximal chord with a lower limit of 80 A. Tumour necrosis factor has been crystallized in a trigonal space group. Our results are in favour of a single trimer in the asymmetric unit. The diffraction extends to 3.5 A.

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