Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jan 15;12(1):56-68.
doi: 10.4239/wjd.v12.i1.56.

Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience

Sari Krepel Volsky  1 , Shlomit Shalitin  1 , Elena Fridman  1 , Michal Yackobovitch-Gavan  1 , Liora Lazar  1 , Rachel Bello  1 , Tal Oron  1 , Ariel Tenenbaum  1 , Liat de Vries  1 , Yael Lebenthal  1
Affiliations

Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience

Sari Krepel Volsky et al. World J Diabetes. .

Abstract

Background: Type 1 diabetes (T1D) contributes to altered lipid profiles and increases the risk of cardiovascular disease (CVD). Youth with T1D may have additional CVD risk factors within the first decade of diagnosis.

Aim: To examine risk factors for dyslipidemia in young subjects with T1D.

Methods: Longitudinal and cross-sectional retrospective study of 170 young subjects with T1D (86 males; baseline mean age 12.2 ± 5.6 years and hemoglobin A1c 8.4% ± 1.4%) were followed in a single tertiary diabetes center for a median duration of 15 years. Predictors for outcomes of lipid profiles at last visit (total cholesterol [TC], triglycerides [TGs], low-density lipoprotein-cholesterol [LDL-c], and high-density lipoprotein-cholesterol [HDL-c]) were analyzed by stepwise linear regression models.

Results: At baseline, 79.5% of the patients had at least one additional CVD risk factor (borderline dyslipidemia/dyslipidemia [37.5%], pre-hypertension/hypertension [27.6%], and overweight/obesity [16.5%]) and 41.6% had multiple (≥ 2) CVD risk factors. A positive family history of at least one CVD risk factor in a first-degree relative was reported in 54.1% of the cohort. Predictors of elevated TC: family history of CVD (β[SE] = 23.1[8.3], P = 0.006); of elevated LDL-c: baseline diastolic blood pressure (DBP) (β[SE] = 11.4[4.7], P = 0.003) and family history of CVD (β[SE] = 20.7[6.8], P = 0.017); of elevated TGs: baseline DBP (β[SE] = 23.8[9.1], P = 0.010) and family history of CVD (β[SE] = 31.0[13.1], P = 0.020); and of low HDL-c levels: baseline DBP (β[SE] = 4.8[2.1], P = 0.022]).

Conclusion: Our findings suggest that elevated lipid profiles are associated with DBP and a positive family history of CVD. It is of utmost importance to prevent and control modifiable risk factors such as these, as early as childhood, given that inadequate glycemic control and elevation in blood pressure intensify the risk of dyslipidemia.

Keywords: Cardiovascular disease risk factors; Children and adolescents; Dyslipidemia; Family history of cardiovascular disease risk factors; Hypertension; Type 1 diabetes.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: All authors confirm that no potential conflicts of interest relevant to this article were reported.

Figures

Figure 1
Figure 1
Number and distribution of multiple cardiovascular disease risk factors (overweight/obesity, pre-hypertension/hypertension, dyslipidemia [elevated low-density lipoprotein-cholesterol/elevated triglyceride/low high-density lipoprotein-cholesterol] and positive family history for cardiometabolic diseases) categorized by sex in childhood and adolescence. No significant differences between males and females (P = 0.210). Bar graphs in black represent the entire cohort, males in white, and females in gray.
Figure 2
Figure 2
Number and distribution of multiple cardiovascular disease risk factors (overweight/obesity, pre-hypertension/hypertension, dyslipidemia [elevated low-density lipoprotein-cholesterol/elevated triglyceride/low high-density lipoprotein-cholesterol] and positive family history for cardiometabolic diseases) categorized by sex at young adulthood. No significant differences between males and females (P = 0.275). Bar graphs in black represent the entire cohort, males in white and females in gray.
See this image and copyright information in PMC

References

    1. Patterson CC, Harjutsalo V, Rosenbauer J, Neu A, Cinek O, Skrivarhaug T, Rami-Merhar B, Soltesz G, Svensson J, Parslow RC, Castell C, Schoenle EJ, Bingley PJ, Dahlquist G, Jarosz-Chobot PK, Marčiulionytė D, Roche EF, Rothe U, Bratina N, Ionescu-Tirgoviste C, Weets I, Kocova M, Cherubini V, Rojnic Putarek N, deBeaufort CE, Samardzic M, Green A. Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989-2013: a multicentre prospective registration study. Diabetologia. 2019;62:408–417. - PubMed
    1. DIAMOND Project Group. Incidence and trends of childhood Type 1 diabetes worldwide 1990-1999. Diabet Med. 2006;23:857–866. - PubMed
    1. Mayer-Davis EJ, Lawrence JM, Dabelea D, Divers J, Isom S, Dolan L, Imperatore G, Linder B, Marcovina S, Pettitt DJ, Pihoker C, Saydah S, Wagenknecht L SEARCH for Diabetes in Youth Study. Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002-2012. N Engl J Med. 2017;376:1419–1429. - PMC - PubMed
    1. Berenson GS, Wattigney WA, Tracy RE, Newman WP 3rd, Srinivasan SR, Webber LS, Dalferes ER Jr, Strong JP. Atherosclerosis of the aorta and coronary arteries and cardiovascular risk factors in persons aged 6 to 30 years and studied at necropsy (The Bogalusa Heart Study) Am J Cardiol. 1992;70:851–858. - PubMed
    1. Singh TP, Groehn H, Kazmers A. Vascular function and carotid intimal-medial thickness in children with insulin-dependent diabetes mellitus. J Am Coll Cardiol. 2003;41:661–665. - PubMed

LinkOut - more resources