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. 2021 Jan 20;16(1):84-92.
doi: 10.18502/jovr.v16i1.8254. eCollection 2021 Jan-Mar.

Medication-induced Uveitis: An Update

Kashif M Iqbal  1 , Madeline W Hay  2 , Parisa Emami-Naeini  3
Affiliations

Medication-induced Uveitis: An Update

Kashif M Iqbal et al. J Ophthalmic Vis Res. .

Abstract

Drug-induced uveitis is an uncommon but important cause of ocular inflammation. Uveitis can be seen in association with various systemic, topical, and intraocular medications. In this article, we review common medications associated with uveitis. Most cases of drug-induced uveitis resolve with termination of the suspected medication with or without administration of topical or systemic steroids. It is important for clinicians to readily identify medications that may cause uveitis in order to provide rapid treatment, avoid consequences of longstanding inflammation, and prevent costly and excessive laboratory testing.

Keywords: Medication; Medication-induced Uveitis; Uveitis.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Fluorescein angiography of a 67-year-old female with history of rheumatoid arthritis treated with etanercept who developed uveitis and retinal vasculitis three months after the initiation of etanercept. Etanercept was discontinued and infliximab was started which resulted in resolution of ocular inflammation.
Figure 2
Figure 2
(A) 77-year-old man with history of malignant skin melanoma treated with nivolumab presented with blurry vision in both eyes. External exam showed poliosis of the eyelashes. Ultrawide field fluorescein angiography showed optic nerve and vascular leakage (B) which improved after intravitreal injection of triamcinolone acetonide.
Figure 3
Figure 3
Inflamed, indurated skin tattoos in a young patient with tattoo uveitis.
See this image and copyright information in PMC

References

    1. Anquetil C, Salem JE, Lebrun-Vignes B, Touhami S, Desbois AC, Maalouf G, et al. Evolving spectrum of drug-induced uveitis at the era of immune checkpoint inhibitors results from the WHO's pharmacovigilance database. J Autoimmun 2020;102454 - PubMed
    1. McCannel C, Holland G, Helm C, Cornell P, Winston J, Rimmer T. Causes of uveitis in the general practice of ophthalmology. Am J Ophthalmol 1996;121:35–46. - PubMed
    1. Deschenes J, Murray PI, Rao NA, Nussenblatt RB. International Uveitis Study Group (IUSG) clinical classification of uveitis. Ocul Immunol Inflamm 2008;16:1–2. - PubMed
    1. Bloch-Michel E, Nussenblatt RB. International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease. Am J Ophthalmol 1987;103:234–235. - PubMed
    1. Jabs DA, Nussenblatt RB, Rosenbaum JT. Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol 2005;140:509–516. - PMC - PubMed