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. 2021 Jan 15:10:611809.
doi: 10.3389/fonc.2020.611809. eCollection 2020.

Prognostic Analysis and Influencing Serum Biomarkers of Patients With Resectable Pancreatic Adenosquamous Cancer

Yusheng Shi  1   2   3   4 , Xinjing Wang  1   2   3   4 , Weize Wu  1   2   3   4 , Junjie Xie  1   2   3   4 , Jiabin Jin  1   2   3   4 , Chenghong Peng  1   2   3   4 , Xiaxing Deng  1   2   3   4 , Hao Chen  1   2   3   4 , Baiyong Shen  1   2   3   4
Affiliations

Prognostic Analysis and Influencing Serum Biomarkers of Patients With Resectable Pancreatic Adenosquamous Cancer

Yusheng Shi et al. Front Oncol. .

Abstract

Objectives: There are few reports about the survival rate of patients with pancreatic adenosquamous cancer (PASC). This study evaluated and analyzed prognostic factors of patients with resectable pancreatic adenosquamous cancer (rPASC), which might fulfill the blank in the research of PASC.

Methods: In this study, we identified and analyzed 55 patients who were diagnosed with rPASC from January 2013 to May 2019 at the Pancreatic Disease Center of the Shanghai Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine. Age, sex, BMI, tumor position, and other important demographic data were collected and analyzed. The follow-up was updated by December 31th, 2019 with a median follow-up of nine months.

Results: Among the 55 patients, 23 (41.8%) patients were female, and the mean age was 62.0 ± 10.3 years. The median overall survival (OS) time was 10 ± 2.1 months, and the median disease-free survival (DFS) time was 4 ± 0.9 months. The 1-year, 3-year, and 5-year survival rates were 40.9, 17.5, and 11.6%, respectively. The multivariate analysis showed that normal serum level of Ca199 (HR = 0.464, 95% CI = 0.222-0.970, P = 0.041) and Ca125 (HR = 0.441, 95% CI = 0.233-0.835, P = 0.012) were independent favorable prognostic factors.

Conclusion: Patients with rPASC had poor survival. The 5-year survival rate was only 11.6%. Normal serum levels of Ca199 and Ca125 were independent favorable prognostic factors that predicted prognosis.

Keywords: Longterm survival; Pancreatic Cancer; Pancreatic adenosquamous cancer; overall survival; pancreatic surgery.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The Relationship between serum level of Ca199 and Ca125 and the OS/PFS of PASC patients.
See this image and copyright information in PMC

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