Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jan 14:7:618506.
doi: 10.3389/fmed.2020.618506. eCollection 2020.

The Potential Roles of Exosomes in Chronic Obstructive Pulmonary Disease

Nan Wang  1 , Qin Wang  2 , Tiantian Du  3 , Abakundana Nsenga Ariston Gabriel  3 , Xue Wang  4 , Li Sun  1 , Xiaomeng Li  1 , Kanghong Xu  1 , Xinquan Jiang  1 , Yi Zhang  5
Affiliations
Review

The Potential Roles of Exosomes in Chronic Obstructive Pulmonary Disease

Nan Wang et al. Front Med (Lausanne). .

Abstract

Currently, chronic obstructive pulmonary disease (COPD) is one of the most common chronic lung diseases. Chronic obstructive pulmonary disease is characterized by progressive loss of lung function due to chronic inflammatory responses in the lungs caused by repeated exposure to harmful environmental stimuli. Chronic obstructive pulmonary disease is a persistent disease, with an estimated 384 million people worldwide living with COPD. It is listed as the third leading cause of death. Exosomes contain various components, such as lipids, microRNAs (miRNAs), long non-coding RNAs(lncRNAs), and proteins. They are essential mediators of intercellular communication and can regulate the biological properties of target cells. With the deepening of exosome research, it is found that exosomes are strictly related to the occurrence and development of COPD. Therefore, this review aims to highlight the unique role of immune-cell-derived exosomes in disease through complex interactions and their potentials as potential biomarkers new types of COPD.

Keywords: COPD; biomarker; exosomes; immune cell; treatment.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Exosome in cell communication. Exosomes are nanovesicles (30–150 nm) that originate formed by early endosomes, late endosomes, and ultimately multivesicular bodies (MVB). Exosomes contain a variety of proteins, lipids, DNA, RNA, and metabolites. The cell body's surface includes major histocompatibility complex (MHC I/II), Tetraspanins (CD9, CD63, CD81, CD82), cell surface proteins ligand. This confers them with functional features. Exosomes can transmit information to target cells by: (1) binding to the cell surface by ligand, (2) endocytosis, (3) direct fusion of extracellular with plasma membranes.
Figure 2
Figure 2
COPD's pathological features are chronic inflammation of the lung parenchyma and surrounding airways, emphysema, and narrowing. Remodeling of the small airways, and exosomes are closely related to the course of this cases. List of previously reported miRNA associated with COPD. COPD, chronic obstructive pulmonary disease. Summary data are based on the following references (, , , –52) for miRNAs and (–56) for lncRNAs.
Figure 3
Figure 3
Exosomes and macrophages promote alveolar inflammation in COPD.
See this image and copyright information in PMC

References

    1. Putcha N, Puhan MA, Hansel NN, Drummond MB, Boyd CM. Impact of co-morbidities on self-rated health in self-reported COPD: an analysis of NHANES 2001-2008. COPD. (2013) 10:324–32. 10.3109/15412555.2012.744963 - DOI - PMC - PubMed
    1. Chen Y, Wang H, Luo G, Dai X. SIRT4 inhibits cigarette smoke extracts-induced mononuclear cell adhesion to human pulmonary microvascular endothelial cells via regulating NF-κB activity. Toxicol Lett. (2014) 226:320–7. 10.1016/j.toxlet.2014.02.022 - DOI - PubMed
    1. Sundar IK, Li D, Rahman I. Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers. J Extracell Vesicles. (2019) 8:1684816. 10.1080/20013078.2019.1684816 - DOI - PMC - PubMed
    1. Salimian J, Mirzaei H, Moridikia A, Harchegani AB, Sahebkar A, Salehi H. Chronic obstructive pulmonary disease: microRNAs and exosomes as new diagnostic and therapeutic biomarkers. J Res Med Sci. (2018) 23:27. 10.4103/jrms.JRMS_1054_17 - DOI - PMC - PubMed
    1. Chen Y, Luo H, Kang N, Guan C, Long Y, Cao J, et al. . Beraprost sodium attenuates cigarette smoke extract-induced apoptosis in vascular endothelial cells. Mol Biol Rep. (2012) 39:10447–57. 10.1007/s11033-012-1924-1 - DOI - PubMed

LinkOut - more resources