Practical recommendations for the allergological risk assessment of the COVID-19 vaccination - a harmonized statement of allergy centers in Germany

Margitta Worm¹, Andrea Bauer², Bettina Wedi³, Regina Treudler⁴, Wolfgang Pfuetzner⁵, Knut Brockow⁶, Timo Buhl⁷, Torsten Zuberbier⁸, Joachim Fluhr⁸, Gerda Wurpts⁹, Ludger Klimek¹⁰, Thilo Jakob¹¹, Hans F Merk¹², Norbert Mülleneisen¹³, Stefani Roeseler¹⁴, Heinrich Dickel¹⁵, Ulrike Raap¹⁶, Jörg Kleine-Tebbe¹⁷

Affiliations

¹ Allergology and Immunology, Department of Dermatology, Venereology and Allergology, Campus Charité Mitte, University Medicine Berlin.
² Clinic and Polyclinic for Dermatology, University Hospital Carl Gustav Carus at the Technical University Dresden.
³ Department of Dermatology, Allergology and Venereology Comprehensive Allergy Center (CAC) Treatment Center for Hereditary Angioedema in the ZSE, Hannover Medical School.
⁴ Clinic of Dermatology, Venereology and Allergology, Leipzig University Medical Center.
⁵ Hesse Allergy Center, Clinic for Dermatology and Allergology, Marburg University Hospital.
⁶ Dermatology Clinic Campus Biederstein, Klinikum rechts der Isar, Technical University of Munich.
⁷ Dermatology Venereology and Allergology Clinic, University Medical Center Göttingen Georg-August-University.
⁸ Department of Dermatology and Allergy, Comprehensive Allergy Center Charité - Universitätsmedizin Berlin, Germany, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health.
⁹ Department of Dermatology and Allergology, University Hospital Aachen.
¹⁰ Center for Rhinology and Allergology of the ENT University Clinic Mannheim, Wiesbaden.
¹¹ Department of Dermatology, Venerology and Allergology, University Hospital Giessen.
¹² Dermatology Clinic, RWTH Aachen University.
¹³ Asthma and Allergy Center, Leverkusen.
¹⁴ Allergy, Asthma and Anaphylaxis Center, Clinic of Pneumology, Allergology, Sleep and Respiratory Medicine, Augustinians Hospital, Cologne.
¹⁵ Department of Allergology, Occupational and Environmental Dermatology, Clinic for Dermatology, Venereology and Allergology, St. Josef Hospital, Ruhr University Bochum.
¹⁶ Department of Experimental Allergology and Immunodermatology, Department of Human Medicine, University of Oldenburg, and.
¹⁷ Allergy and Asthma Center Westend, Berlin, Germany.

PMID: 33521511
PMCID: PMC7841415
DOI: 10.5414/ALX02225E

Practical recommendations for the allergological risk assessment of the COVID-19 vaccination - a harmonized statement of allergy centers in Germany

Margitta Worm et al. Allergol Select. 2021.

. 2021 Jan 26:5:72-76.

doi: 10.5414/ALX02225E. eCollection 2021.

Authors

Affiliations

¹ Allergology and Immunology, Department of Dermatology, Venereology and Allergology, Campus Charité Mitte, University Medicine Berlin.
² Clinic and Polyclinic for Dermatology, University Hospital Carl Gustav Carus at the Technical University Dresden.
³ Department of Dermatology, Allergology and Venereology Comprehensive Allergy Center (CAC) Treatment Center for Hereditary Angioedema in the ZSE, Hannover Medical School.
⁴ Clinic of Dermatology, Venereology and Allergology, Leipzig University Medical Center.
⁵ Hesse Allergy Center, Clinic for Dermatology and Allergology, Marburg University Hospital.
⁶ Dermatology Clinic Campus Biederstein, Klinikum rechts der Isar, Technical University of Munich.
⁷ Dermatology Venereology and Allergology Clinic, University Medical Center Göttingen Georg-August-University.
⁸ Department of Dermatology and Allergy, Comprehensive Allergy Center Charité - Universitätsmedizin Berlin, Germany, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health.
⁹ Department of Dermatology and Allergology, University Hospital Aachen.
¹⁰ Center for Rhinology and Allergology of the ENT University Clinic Mannheim, Wiesbaden.
¹¹ Department of Dermatology, Venerology and Allergology, University Hospital Giessen.
¹² Dermatology Clinic, RWTH Aachen University.
¹³ Asthma and Allergy Center, Leverkusen.
¹⁴ Allergy, Asthma and Anaphylaxis Center, Clinic of Pneumology, Allergology, Sleep and Respiratory Medicine, Augustinians Hospital, Cologne.
¹⁵ Department of Allergology, Occupational and Environmental Dermatology, Clinic for Dermatology, Venereology and Allergology, St. Josef Hospital, Ruhr University Bochum.
¹⁶ Department of Experimental Allergology and Immunodermatology, Department of Human Medicine, University of Oldenburg, and.
¹⁷ Allergy and Asthma Center Westend, Berlin, Germany.

PMID: 33521511
PMCID: PMC7841415
DOI: 10.5414/ALX02225E

Abstract

Severe allergic reactions to vaccines are very rare. Single severe reactions have occurred worldwide after vaccination with the new mRNA-based COVID-19 vaccines. PEG2000 is discussed as a possible trigger. We provide guidance on risk assessment regarding COVID-19 vaccination in patients with allergic diseases and suggest a standardized, resource-oriented diagnostic and therapeutic procedure. Reports of severe allergic reactions in the context of COVID-19 vaccination can be made via www.anaphylaxie.net using an online questionnaire.

Keywords: COVID-19 vaccination; allergy; anaphylaxis; polyethylene glycol; polysorbate 80; skin test.

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Figures

**Figure 1.. Proposed diagnostic allergological procedure in case of a possible vaccination risk assessment.**

See this image and copyright information in PMC

References

1. www.rki.de/epidbull
1. McNeil MM Weintraub ES Duffy J Sukumaran L Jacobsen SJ Klein NP Hambidge SJ Lee GM Jackson LA Irving SA King JP Kharbanda EO Bednarczyk RA DeStefano F Risk of anaphylaxis after vaccination in children and adults. J Allergy Clin Immunol. 2016; 137: 868–878. - PMC - PubMed
1. CDC. COVID-19 Response Team, FDA. Allergic reactions including anaphylaxis after receipt of the first dose of Pfizer-BioNTech COVID-19 vaccine – United States, December 14 – 23, 2020. Centers for Disease Control and Prevention. - PMC - PubMed
1. https://www.pei.de/DE/newsroom/positionen/covid-19-impfstoffe/stellungna...
1. Kleine-Tebbe J Klimek L Hamelmann E Pfaar O Taube C Wagenmann M Werfel T Worm M Severe allergic reactions to the COVID-19 vaccine – statement and practical consequences. Allergol Select. 2021; 5: 26–28. - PMC - PubMed

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Practical recommendations for the allergological risk assessment of the COVID-19 vaccination - a harmonized statement of allergy centers in Germany

Affiliations

Practical recommendations for the allergological risk assessment of the COVID-19 vaccination - a harmonized statement of allergy centers in Germany

Authors

Affiliations

Abstract

Figures

References

LinkOut - more resources

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