Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment

Maura Corsetti^{1

2}, Steven Brown³, Giuseppe Chiarioni^{4

5}, Eirini Dimidi⁶, Thomas Dudding⁷, Anton Emmanuel⁸, Mark Fox^{9

10}, Alexander C Ford^{11

12}, Pasquale Giordano¹³, Ugo Grossi¹⁴, Michelle Henderson¹⁵, Charles H Knowles¹⁶, P Ronan O'Connell¹⁷, Eamonn M M Quigley¹⁸, Magnus Simren^{5

19}, Robin Spiller^{1

2}, Kevin Whelan⁶, William E Whitehead⁵, Andrew B Williams²⁰, S Mark Scott¹⁶

Affiliations

¹ NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.
² School of Medicine, University of Nottingham and Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK.
³ Department of Surgery, University of Sheffield, Sheffield, UK.
⁴ Division of Gastroenterology, University of Verona, AOUI Verona, Verona, Italy.
⁵ Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁶ Department of Nutritional Sciences, King's College London, London, UK.
⁷ University of Southampton NHS Trust, Southampton, UK.
⁸ GI Physiology Unit, UCL & UCLH, London, UK.
⁹ Division of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.
¹⁰ Digestive Function: Basel, Laboratory and Clinic for Motility Disorders and Functional Gastrointestinal Diseases, Centre for Integrative Gastroenterology, Klinik Arlesheim, Arlesheim, Switzerland.
¹¹ Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.
¹² Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.
¹³ Department of Colorectal Surgery, Barts health NHS Trust, London, UK.
¹⁴ Tertiary Referral Pelvic Floor and Incontinence Centre, Regional Hospital Treviso, University of Padua, Padua, Italy.
¹⁵ Durham Bowel Dysfunction Service, Old Trust Headquarters, University Hospital of North Durham, Durham, UK.
¹⁶ National Bowel Research Centre and GI Physiology Unit, Centre for Neuroscience, Surgery & Trauma, Blizard Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
¹⁷ Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland.
¹⁸ Lynda K and David M Center for Gastrointestinal Disorders, Houston Methodist Hospital and Weill Cornell Medical College, Houston, Texas, USA.
¹⁹ Department of Internal Medicine & Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
²⁰ Guy's and St Thomas, NHS Foundation Trust, London, UK.

PMID: 33522079
DOI: 10.1111/nmo.14070

Free article

Review

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment

Maura Corsetti et al. Neurogastroenterol Motil. 2021 Jul.

Free article

. 2021 Jul;33(7):e14070.

doi: 10.1111/nmo.14070. Epub 2021 Feb 1.

Authors

Affiliations

¹ NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.
² School of Medicine, University of Nottingham and Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK.
³ Department of Surgery, University of Sheffield, Sheffield, UK.
⁴ Division of Gastroenterology, University of Verona, AOUI Verona, Verona, Italy.
⁵ Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁶ Department of Nutritional Sciences, King's College London, London, UK.
⁷ University of Southampton NHS Trust, Southampton, UK.
⁸ GI Physiology Unit, UCL & UCLH, London, UK.
⁹ Division of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.
¹⁰ Digestive Function: Basel, Laboratory and Clinic for Motility Disorders and Functional Gastrointestinal Diseases, Centre for Integrative Gastroenterology, Klinik Arlesheim, Arlesheim, Switzerland.
¹¹ Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.
¹² Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.
¹³ Department of Colorectal Surgery, Barts health NHS Trust, London, UK.
¹⁴ Tertiary Referral Pelvic Floor and Incontinence Centre, Regional Hospital Treviso, University of Padua, Padua, Italy.
¹⁵ Durham Bowel Dysfunction Service, Old Trust Headquarters, University Hospital of North Durham, Durham, UK.
¹⁶ National Bowel Research Centre and GI Physiology Unit, Centre for Neuroscience, Surgery & Trauma, Blizard Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
¹⁷ Centre for Colorectal Disease, St Vincent's University Hospital, Dublin, Ireland.
¹⁸ Lynda K and David M Center for Gastrointestinal Disorders, Houston Methodist Hospital and Weill Cornell Medical College, Houston, Texas, USA.
¹⁹ Department of Internal Medicine & Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
²⁰ Guy's and St Thomas, NHS Foundation Trust, London, UK.

PMID: 33522079
DOI: 10.1111/nmo.14070

Abstract

Background: Chronic constipation is a prevalent disorder that affects quality of life of patients and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as to which treatments to use and when. Over a decade ago, a Neurogastroenterology and Motility journal supplement devoted to the investigation and management of constipation was published (Neurogastroenterol Motil 2009;21(Suppl 2):1). In October 2018, the 3rd London Masterclass, entitled "Contemporary management of constipation" was held. The faculty members of this symposium were invited to write two reviews to present a collective synthesis of talks presented and discussions held during this meeting. The first review addresses epidemiology, diagnosis, clinical associations, pathophysiology, and investigation.

Purpose: The present is the second of these reviews, providing contemporary perspectives and clinical challenges regarding behavioral, conservative, medical, and surgical treatments for patients presenting with constipation. It includes a management algorithm to guide clinical practice.

Keywords: IBS-C; algorithm; constipation; treatment.

PubMed Disclaimer

References

REFERENCES

1. Cook IJ, Talley NJ, Benninga MA, Rao SS, Scott SM. Chronic constipation: overview and challenges. Neurogastroenterol Motil. 2009;21(Suppl 2):1-8.
1. SACN Carbohydrates and Health Report: The Scientific Advisory Committee on Nutrition recommendations on carbohydrates, including sugars and fibre. July 2015. https://www.gov.uk/government/publications/sacn-carbohydrates-and-health.... Accessed June 01, 2020.
1. Orak S, Akgün S, Orhan H.Investigation of nutrition habits of Süleyman Demirel University students. Journal of SDU Faculty of Medicine 2006 dergipark.org.tr.
1. Shen L, Huang C, Lu X, Xu X, Jiang Z, Zhu C. Lower dietary fibre intake, but not total water consumption, is associated with constipation: a population-based analysis. J Hum Nutr Diet. 2019;32:422-431.
1. Mearin F, Ciriza C, Minguez M, et al. Clinical Practice Guideline: irritable bowel syndrome with constipation and functional constipation in the adult. Rev Esp Enferm Dig. 2016;108:332-363.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

MR/N026810/1/MRC_/Medical Research Council/United Kingdom

LinkOut - more resources

Full Text Sources
- Zurich Open Access Repository and Archive
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment

Affiliations

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical