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Randomized Controlled Trial
. 2021 Jun;56(6):1427-1433.
doi: 10.1002/ppul.25287. Epub 2021 Feb 1.

Vitamin-D supplementation as an adjunct to standard treatment of asthma in children: A randomized controlled trial (ViDASTA Trial)

Chirag Thakur  1 , Jogender Kumar  2 , Prawin Kumar  1 , Jagdish Prasad Goyal  1 , Kuldeep Singh  1 , Atul Gupta  3
Affiliations
Randomized Controlled Trial

Vitamin-D supplementation as an adjunct to standard treatment of asthma in children: A randomized controlled trial (ViDASTA Trial)

Chirag Thakur et al. Pediatr Pulmonol. 2021 Jun.

Abstract

Objective: To determine the role of vitamin D supplementation as an adjunct to standard treatment in childhood asthma.

Study design: In this placebo-controlled, blinded, randomized controlled trial, we enrolled 60 children aged 6 to 11 years with moderate persistent asthma and randomly assigned them into intervention (2000 IU per day of vitamin D) and placebo groups (n = 30 each). The primary outcome was asthma control as assessed by the childhood asthma control test (C-ACT) scores at 12 weeks post-randomization. The secondary outcomes were improvement in the forced expiration in 1 s (FEV1 ), fractional exhaled nitric oxide (FeNO), asthma exacerbations, use of systemic steroids, number of emergency visits, post-intervention vitamin D levels, and adverse outcomes. We analyzed by intention to treat.

Results: There was no significant difference between the C-ACT score in the two groups (median [first-third quartile] scores were 25 [24-26] in both groups, p = 0.7). Also, there was no significant difference between the two groups in terms of the FEV1 , FeNO, number of exacerbations, emergency visits, hospital admissions, and adverse outcomes. However, the post-intervention vitamin D levels (ng/ml) were significantly higher in the intervention group (35.5 vs. 18.8; p < 0.001). As compared to the baseline, both the groups showed better asthma control at 12 weeks post-intervention, irrespective of the type of intervention.

Conclusion: Vitamin-D supplementation as an adjunct to standard treatment does not improve asthma control in children.

Keywords: FeNO; asthma; childhood asthma control test; children; spirometry; vitamin D.

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References

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