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Editorial
. 2021 Feb;64(2):158-160.
doi: 10.1165/rcmb.2020-0487ED.

Dampening the Fire: A Negative Feedback Loop in Acute Respiratory Distress Syndrome

Jing Liu  1 , Marc A Sala  2 , Jiyeon Kim  3
Affiliations
Editorial

Dampening the Fire: A Negative Feedback Loop in Acute Respiratory Distress Syndrome

Jing Liu et al. Am J Respir Cell Mol Biol. 2021 Feb.
No abstract available

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Figures

Figure 1.
Figure 1.
miR-574-5p–mediated negative feedback loop for LPS–TLR4 (Toll-like receptor 4) signaling during acute respiratory distress syndrome (ARDS). In the context of LPS-induced acute lung injury/ARDS in an experimental animal model, binding of LPS to TLR4 triggers the inflammatory response through NF-κB–dependent inflammatory gene expression and NLRP3 inflammasome activation. In addition, HMGB1 (high-mobility group box 1) is released into extracellular space, where it activates TLR4 and amplifies the inflammatory response. On the other hand, NF-κB induces miR-574-5p, which targets HMGB1 mRNA for degradation, thereby restraining the inflammatory response. NLRP3 = NLR family pyrin domain containing 3.
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References

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