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. 2021 Feb 1;21(1):134.
doi: 10.1186/s12879-021-05841-1.

Clinical characteristics, management and health related quality of life in young to middle age adults with COVID-19

Chiara Temperoni  1 , Stefania Grieco  1 , Zeno Pasquini  1   2 , Benedetta Canovari  1 , Antonio Polenta  1   2 , Umberto Gnudi  3 , Roberto Montalti  4 , Francesco Barchiesi  5   6
Affiliations

Clinical characteristics, management and health related quality of life in young to middle age adults with COVID-19

Chiara Temperoni et al. BMC Infect Dis. .

Abstract

Background: The outbreak of COVID-19 has rapidly spread to Italy, including Pesaro-Urbino province. Data on young to middle age adults with COVID-19 are lacking. We report the characteristics, management and health-related quality of life (HRQoL) in patients with COVID-19 aging ≤50 years.

Methods: A retrospective analysis was performed in all patients ≤50 years with a confirmed diagnosis of COVID-19 admitted to Emergency department (ED) of San Salvatore Hospital in Pesaro from February 28th to April 8th, 2020. Data were collected from electronical medical records. HRQoL was investigated after 1 month from hospital discharge using the SF-36 questionnaire. Outcomes were evaluated between hospitalized and not hospitalized patients.

Results: Among 673 patients admitted to the ED and diagnosed with COVID-19, 104 (15%) were ≤ 50 years old: 74% were discharged at home within 48 h, 26% were hospitalized. Fever occurred in 90% of the cases followed by cough (56%) and dyspnoea (34%). The most frequent coexisting conditions were hypertension (11%), thyroid dysfunction (8%) and neurological and/or mental disorders [NMDs] (6%). Mean BMI was 27. Hypokalaemia and NMDs were significantly more common in patients who underwent mechanical ventilation. Regardless of hospitalization, there was an impairment in both the physical and mental functioning.

Conclusions: Overweight and hypertension are frequent conditions in young to middle age adults with COVID-19. Hypokalaemia and NMDs are commonly associated with progressive disease. A significant impact on HRQoL in the early stage of post-discharge is common in this population.

Keywords: COVID-19; Health related quality of life; Respiratory distress; SARS-Cov-2; Young to middle age adults.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Distribution of Patients with Covid-19 from the seven italian regions mainly involved in the pandemic (a) and across Marche region (b). Laboratory-confirmed cases of Covid-19 throughout Northern and Center Italy according to the Italian Civil Protection as of May 8, 2020 (a) and across Marche region according to the GORES (Operative Regional Group for Sanitary Emergencies) as of May 8, 2020. Map produced by the Authors
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