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Review
. 2021 May;30(5):717-722.
doi: 10.1111/exd.14291. Epub 2021 Feb 13.

Mohs micrographic surgery in dermatofibrosarcoma protuberans: Rate and risk factors for recurrence in a prospective cohort study from the Spanish Registry of Mohs Surgery (REGESMOHS) and review of the literature

Lula María Nieto-Benito  1 , Cristina Ciudad-Blanco  1   2 , Onofre Sanmartin-Jimenez  3 , Joan R Garces  4   5 , Manuel A Rodríguez-Prieto  6 , Eva Vilarrasa  4   5 , Esther de Eusebio-Murillo  7 , Román Miñano-Medrano  8 , Begoña Escutia-Muñoz  9 , Beatriz Gonzalez-Sixto  10 , Juan L Artola-Igarza  11 , Alberto Alfaro Rubio  12 , Pedro Redondo  13 , Yolanda Delgado-Jiménez  14   15 , Julia M Sánchez-Schmidt  16 , Irati Allende-Markixana  17 , María L Alonso-Pacheco  18 , Beatriz García-Bracamonte  19 , Pablo de la Cueva Dobao  20 , Raquel Navarro-Tejedor  15 , Ricardo Suarez-Fernández  1 , Lucia Carnero-González  21 , Hugo Vázquez-Veiga  22 , Lucia Barchino-Ortiz  2 , Verónica Ruiz-Salas  4 , Pedro Sánchez-Sambucety  6 , José L López-Estebaranz  8 , Rafael Botella-Estrada  9 , Carlos Feal-Cortizas  10 , Antonio Martorell Calatayud  12 , Pilar Gil  13 , Victoriano Morales-Gordillo  14 , Agustí Toll-Abelló  16 , Izascun Ocerin-Guerra  17 , Matías Mayor-Arenal  18 , Carmen Garcia-Donoso  19 , Natividad Cano-Martinez  2   20 , Laura Sainz-Gaspar  22 , Miguel A Descalzo  23 , Ignacio Garcia-Doval  23 ; REGESMOHS (Registro Español de Cirugía de Mohs)
Affiliations
Review

Mohs micrographic surgery in dermatofibrosarcoma protuberans: Rate and risk factors for recurrence in a prospective cohort study from the Spanish Registry of Mohs Surgery (REGESMOHS) and review of the literature

Lula María Nieto-Benito et al. Exp Dermatol. 2021 May.

Abstract

Characterization of patients, surgery procedures and the risk factors for dermatofibrosarcoma protuberans (DFSP) recurrences is poorly defined. In this study, we aimed to describe the demographics, tumor characteristics and interventions of DFSP treated with Mohs micrographic surgery (MSS) to determine the rate and risk factors for recurrence. Data were collected from REGESMOHS, a nationwide prospective cohort study of patients treated with MMS in Spain. From July 2013 to February 2020, 163 patients with DFSP who underwent MMS were included. DFSP was mostly located on trunk and extremities. Recurrent tumors had deeper tumor invasion and required higher number of MMS stages. Paraffin MMS was the most frequently used technique. Overall recurrence rate was 0.97 cases/100 person-years (95% IC = 0.36-2.57). No differences were found in epidemiological, tumor, surgery characteristics or surgical technique (frozen or paraffin MMS [p = 0.6641]) in terms of recurrence. Median follow-up time was 28.6 months with 414 patient-years of follow-up. In conclusion, we found an overall low recurrence rate of DFSP treated with MMS. None of the studied risk factors, including MMS techniques, was associated with higher risk for recurrence.

Keywords: DFSP; frozen mms; local; mohs surgery; neoplasm recurrence; paraffin mms; skin neoplasms.

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References

REFERENCES

    1. Ugurel S, Kortmann R-D, Mohr P, et al. S1 Guidelines for dermatofibrosarcoma protuberans (DFSP) - update 2018. J Dtsch Dermatol Ges. 2019;17:663-668. https://doi.org/10.1111/ddg.13849.
    1. Cohen DK, Goldberg DJ. Mohs micrographic surgery: past, present and future. Dermatol Surg. 2019;45:29-39. https://doi.org/10.1097/DSS.0000000000001701.
    1. Malan M, Xuejimgzi W, Quan SJ. The efficacy of Mohs micrographic surgery over the traditional wide local excision surgery in the cure of dermatofibrosarcoma protuberans. Pan Afr Med J. 2019;33:297. https://doi.org/10.11604/pamj.2019.33.297.17692.
    1. Saiag P, Grob J-J, Lebbe C, et al. Diagnosis and treatment of dermatofibrosarcoma protuberans. European consensus-based interdisciplinary guideline. Eur J Cancer. 2015;51(17):2604-2608. https://doi.org/10.1016/j.ejca.2015.06.108.
    1. Llombart B, Serra C, Requena C, et al. Guidelines for diagnosis and treatment of cutaneous sarcomas: dermatofibrosarcoma protuberans. Actas Dermosifiliogr. 2018;109:868-877. https://doi.org/10.1016/j.ad.2018.05.006.

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