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Review
. 2021 Mar 21;50(6):3647-3655.
doi: 10.1039/d0cs01118e. Epub 2021 Feb 1.

Antiviral drug discovery: preparing for the next pandemic

Catherine S Adamson  1 , Kelly Chibale, Rebecca J M Goss, Marcel Jaspars, David J Newman, Rosemary A Dorrington
Affiliations
Review

Antiviral drug discovery: preparing for the next pandemic

Catherine S Adamson et al. Chem Soc Rev. .

Erratum in

Abstract

Clinically approved antiviral drugs are currently available for only 10 of the more than 220 viruses known to infect humans. The SARS-CoV-2 outbreak has exposed the critical need for compounds that can be rapidly mobilised for the treatment of re-emerging or emerging viral diseases, while vaccine development is underway. We review the current status of antiviral therapies focusing on RNA viruses, highlighting strategies for antiviral drug discovery and discuss the challenges, solutions and options to accelerate drug discovery efforts.

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