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Review
. 2021 May 1;1867(5):166097.
doi: 10.1016/j.bbadis.2021.166097. Epub 2021 Jan 29.

PPARs in liver physiology

Alexandre Berthier  1 , Manuel Johanns  1 , Francesco Paolo Zummo  1 , Philippe Lefebvre  2 , Bart Staels  3
Affiliations
Free article
Review

PPARs in liver physiology

Alexandre Berthier et al. Biochim Biophys Acta Mol Basis Dis. .
Free article

Abstract

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and transcriptional modulators with crucial functions in hepatic and whole-body energy homeostasis. Besides their well-documented roles in lipid and glucose metabolism, emerging evidence also implicate PPARs in the control of other processes such as inflammatory responses. Recent technological advances, such as single-cell RNA sequencing, have allowed to unravel an unexpected complexity in the regulation of PPAR expression, activity and downstream signaling. Here we provide an overview of the latest advances in the study of PPARs in liver physiology, with a specific focus on formerly neglected aspects of PPAR regulation, such as tissular zonation, cellular heterogeneity, circadian rhythms, sexual dimorphism and species-specific features.

Keywords: Circadian rhythm; Liver; PPARs; Physiology; Sexual dimorphism; Zonation.

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