Initialization is critical for preserving global data structure in both t-SNE and UMAP

Affiliations

¹ Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany. dmitry.kobak@uni-tuebingen.de.
² Applied Mathematics Program, Yale University, New Haven, CT, USA. george.linderman@yale.edu.

Comment

Dmitry Kobak et al. Nat Biotechnol. 2021 Feb.

. 2021 Feb;39(2):156-157.

doi: 10.1038/s41587-020-00809-z. Epub 2021 Feb 1.

¹ Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany. dmitry.kobak@uni-tuebingen.de.
² Applied Mathematics Program, Yale University, New Haven, CT, USA. george.linderman@yale.edu.

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Comment on

Dimensionality reduction for visualizing single-cell data using UMAP.
Becht E, McInnes L, Healy J, Dutertre CA, Kwok IWH, Ng LG, Ginhoux F, Newell EW. Becht E, et al. Nat Biotechnol. 2018 Dec 3. doi: 10.1038/nbt.4314. Online ahead of print. Nat Biotechnol. 2018. PMID: 30531897

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