Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar;27(3):264-267.
doi: 10.1111/tbj.14171. Epub 2021 Feb 1.

MYC and NOTCH1-positive postradiation cutaneous angiosarcoma of the breast

Tiffany G Sheu  1 , Kelly K Hunt  2 , Lavinia P Middleton  3
Affiliations

MYC and NOTCH1-positive postradiation cutaneous angiosarcoma of the breast

Tiffany G Sheu et al. Breast J. 2021 Mar.

Abstract

Postradiation cutaneous angiosarcoma of the breast is a rare, delayed complication of adjuvant radiation treatment for breast carcinoma and is associated with a worse prognosis than the original primary cancer. Recent studies have characterized the diagnostic utility of MYC and NOTCH1 receptor expression as markers for secondary radiation-associated angiosarcomas. Herein, we report an exophytic secondary breast angiosarcoma with MYC and NOTCH1 immunoreactivity. This case illustrates the utility of these markers for the identification of radiation-associated angiosarcoma with MYC and NOTCH1 expression, potential for targeted therapy and need to identify patients for further studies of the clinicopathologic and prognostic significance.

Keywords: MYC; NOTCH1; angiosarcoma; breast carcinoma.

PubMed Disclaimer

References

REFERENCES

    1. Khan JA, Maki RG, Ravi R. Pathologic angiogenesis of malignant vascular sarcomas: implications for treatment. J Clin Oncol. 2018;36:194-201.
    1. Wang XY, Jakowski J, Tawfik OW, Thomas PA, Fan F. Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 years. Ann Diagn Pathol. 2009;13:147-150.
    1. Mentzel T, Schildhaus HU, Palmedo G, Buttner R, Kutzner H. Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases. Mod Pathol. 2012;25:75-85.
    1. Fraga-Guedes C, Andre S, Mastropasqua MG, et al. Angiosarcoma and atypical vascular lesions of the breast: diagnostic and prognostic role of MYC gene amplification and protein expression. Breast Cancer Res Treat. 2015;151:131-140.
    1. Ginter PS, Mosquera JM, MacDonald TY, D’Alfonso TM, Rubin MA, Shin SJ. Diagnostic utility of MYC amplification and anti-MYC immunohistochemistry in atypical vascular lesions, primary or radiation induced mammary angiosarcomas, and primary angiosarcomas of other sites. Hum Pathol. 2014;45:709-716.

Supplementary concepts

LinkOut - more resources