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Review
. 2021 Mar;78(3):867-878.
doi: 10.1007/s00284-021-02353-8. Epub 2021 Feb 2.

Neisseria gonorrhoeae Antimicrobial Resistance: Past to Present to Future

Georgina L Aitolo  1 , Oluyomi S Adeyemi  2 , Boluwatife L Afolabi  3 , Akinyomade O Owolabi  4
Affiliations
Review

Neisseria gonorrhoeae Antimicrobial Resistance: Past to Present to Future

Georgina L Aitolo et al. Curr Microbiol. 2021 Mar.

Abstract

Neisseria gonorrhoeae (gonococcus) is a Gram-negative bacterium that causes gonorrhoea-a sexually transmitted disease. This gonococcus has progressively developed resistance to most of the available antimicrobials. Only a few countries around the world have been able to run extensive surveillance programmes on gonococcal infection and antimicrobial resistance, raising a global concern. Thus, this review focuses on the mechanisms of resistance to recommended antimicrobials in the past and present time. The approaches by the scientific community in the development of novel technologies such as whole-genome sequencing to predict antimicrobial resistance, track gonococcal transmission, as well as, introduce new therapeutics like Solithromycin, Zoliflodacin, and Gepotidacin were also discussed.

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References

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