Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May;476(5):2111-2124.
doi: 10.1007/s11010-021-04053-0. Epub 2021 Jan 29.

The role of exosomal microRNAs in central nervous system diseases

Yifei Yu  1 , Kun Hou  2 , Tong Ji  1 , Xishu Wang  3 , Yining Liu  3 , Yangyang Zheng  1 , Jinying Xu  1 , Yi Hou  4 , Guangfan Chi  5
Affiliations
Review

The role of exosomal microRNAs in central nervous system diseases

Yifei Yu et al. Mol Cell Biochem. 2021 May.

Abstract

MicroRNAs (miRNA), endogenous non-coding RNAs approximately 22 nucleotides long, regulate gene expression by mediating translational inhibition or mRNA degradation. Exosomes are a tool for intercellular transmission of information in which miRNA exchange plays an important role. Under pathophysiological conditions in the central nervous system (CNS), cellular transmission of exosomal miRNAs can regulate signaling pathways. Exosomal miRNAs are involved in the occurrence and development of diverse CNS diseases, such as traumatic brain injury, spinal cord injury, stroke, neurodegenerative diseases, epilepsy, and glioma. The use of exosomes as transport vehicles for certain miRNAs provides a novel therapeutic strategy for CNS diseases. Furthermore, the exosomes in body fluids change with the occurrence of diseases, indicating that subtle changes in physiological and pathological processes in vivo could be recognized by analyzing exosomes. Exosomal analysis is expected to act as a novel tool for diagnosis and prediction of neurological diseases. In this review, we present the current understanding of the implications of miRNAs in CNS diseases and summarize the role and mechanism of action of exosomal miRNA in nervous system disease models.

Keywords: Biomarker; Central nervous system; Exosome; Intercellular communication; MicroRNA.

PubMed Disclaimer

References

    1. He C, Zheng S, Luo Y et al (2018) Exosome Theranostics: Biology and Translational Medicine [J]. Theranostics 8(1):237–255 - PubMed - PMC
    1. Urbanelli L, Buratta S, Sagini K et al (2015) Exosome-based strategies for Diagnosis and Therapy [J]. Recent Pat CNS Drug Discov 10(1):10–27 - PubMed
    1. Qing L, Chen H, Tang J et al (2018) Exosomes and Their MicroRNA Cargo: New Players in Peripheral Nerve Regeneration [J]. Neurorehabil Neural Repair 32(9):765–776 - PubMed - PMC
    1. Anel A, Gallego-Lleyda A, De Miguel D et al (2019) Role of Exosomes in the Regulation of T-cell Mediated Immune Responses and in Autoimmune Disease [J]. Cells. https://doi.org/10.3390/cells8020154 - DOI - PubMed - PMC
    1. Wu P, Zhang B, Shi H et al (2018) MSC-exosome: A novel cell-free therapy for cutaneous regeneration [J]. Cytotherapy 20(3):291–301 - PubMed

Substances

LinkOut - more resources