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Review
. 2021 Feb 1;131(3):e146134.
doi: 10.1172/JCI146134.

Turning lead into gold: reprogramming retinal cells to cure blindness

Seth Blackshaw  1   2   3   4   5 , Joshua R Sanes  6   7
Affiliations
Review

Turning lead into gold: reprogramming retinal cells to cure blindness

Seth Blackshaw et al. J Clin Invest. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: SB is a cofounder and stockholder of CDI Labs. JRS is a consultant for Biogen.

Figures

Figure 1
Figure 1. Summary of three different mechanisms by which reported observations of photoreceptor and RGC replacement are known or proposed to reflect alternative effects.
Observation of GFP+ photoreceptors in host retinas following transplantation of GFP+ donor photoreceptor precursors was initially interpreted as evidence of integration of transplanted photoreceptors, but was later shown to actually reflect cytoplasmic transfer from donor to host. More recent studies reporting AAV-mediated reprogramming of Müller glia to photoreceptors or RGCs may instead reflect ectopic expression of glia-specific minipromoter constructs in retinal neurons. Finally, studies reporting rescue of photoreceptor function in rd1 mice following transplantation of fibroblasts treated with small molecules to induce expression of photoreceptor-specific genes may reflect neurotrophic effects of transplanted cells. ERG, electroretinogram.
See this image and copyright information in PMC

References

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