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. 2021 Mar:51:102199.
doi: 10.1016/j.scr.2021.102199. Epub 2021 Jan 26.

Establishment of iPSC (KRIBBi001-A) from CD34+ group O D-negative bone marrow blood

Jieun Kim  1 , Hyebin Koh  2 , Xing Zhen  3 , Dong-Seok Lee  3 , Hye-Yeong Ha  4 , Jong-Hee Lee  5
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Free article

Establishment of iPSC (KRIBBi001-A) from CD34+ group O D-negative bone marrow blood

Jieun Kim et al. Stem Cell Res. 2021 Mar.
Free article

Abstract

Human induced pluripotent stem cells with indefinite propagation in vitro provide a potential donor source of cells including erythroid cells for human therapy. Since group O D-negative (RhD-) blood cells are considered as universal donors for transfusion, it is compelling to derive iPSC line from group O/RhD- sample as a new cellular source to generate universal RBCs. The resulting iPSC line derived from group O/RhD- somatic source showed typical features of pluripotent stem cells and could provide an unprecedented cellular tool to develop universal therapeutics for blood transfusion.

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