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. 2021 Oct;225(5):441-444.
doi: 10.1055/a-1345-9835. Epub 2021 Feb 2.

[Herpes Simplex Virus Infection in Two Premature Infants - Diagnostic and Therapeutic Management]

[Article in German]
Roland Haase  1   2 , Gregor Seliger  3 , Jan Baier  1
Affiliations

[Herpes Simplex Virus Infection in Two Premature Infants - Diagnostic and Therapeutic Management]

[Article in German]
Roland Haase et al. Z Geburtshilfe Neonatol. 2021 Oct.

Abstract
in English, German

Herpes simplex virus type 1 or 2 (HSV 1/2)-related infections in neonates are rare but associated with high morbidity and mortality, especially if specific treatment is delayed. Due to immaturity of the immunological system, premature infants are particularly at risk. In addition, symptoms of neonatal HSV infections may imitate prematurity-related problems, such as sepsis. So, a thorough patient's history and appropriate diagnostic measures are important to confirm the diagnosis. We present 2 premature infants with systemic HSV infections and discuss diagnostic and therapeutic management. Both were treated with intravenous acyclovir followed by enteral aciclovir suppressive therapy.

Herpes simplex Virus Typ 1 oder 2 (HSV-1/2) Infektionen bei Neugeborenen sind selten, aber insbesondere bei systemischen Verlauf mit einer hohen Morbidität und Mortalität belastet. Frühgeborene gehören aufgrund ihrer immunologischen Unreife und der häufig unspezifischen, Sepsis-ähnlichen Klinik einer HSV-1/2 Infektion zu einer besonders gefährdeten Gruppe. Wir stellen das diagnostische und therapeutische Management bei 2 unreifen Frühgeborenen mit systemischer HSV Infektion vor. Beide erhielten entsprechend aktuellen Empfehlungen nach initialer parenteraler Intensivtherapie eine orale Aciclovir Suppressionstherapie.

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Conflict of interest statement

Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht.

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