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Comparative Study
. 2021 Jan 29;100(4):e23325.
doi: 10.1097/MD.0000000000023325.

Comparison of the 1-year survival rate in infants with congenital heart disease diagnosed by prenatal and postnatal ultrasound: A retrospective study

Bing Han  1   2 , Yi Tang  3 , Xueling Qu  2 , Chuanjun Deng  2 , Xing Wang  2 , Jie Li  1
Affiliations
Comparative Study

Comparison of the 1-year survival rate in infants with congenital heart disease diagnosed by prenatal and postnatal ultrasound: A retrospective study

Bing Han et al. Medicine (Baltimore). .

Abstract

The impact of prenatal diagnosis on the survival outcome of infants with congenital heart disease (CHD) is still unclear. This study aimed to compare the 1-year survival rate between the prenatally and postnatally diagnosed infants with CHDs.A single-center population-based retrospective cohort study was performed on data from all infants diagnosed with CHD born between January 1998 and December 2017. Among infants with isolated CHDs, the 1-year Kaplan-Meier survival probabilities for prenatal and postnatal diagnosis were estimated. Cox proportional hazard ratios were adjusted for critical CHD (CCHD) status and gestational age.A total of 424 (40 prenatally and 384 postnatally) diagnosed infants with CHDs were analyzed. Compared with non-CCHDs, infants with CCHDs were more likely to be prenatally diagnosed (55.0% vs 18.0%; P < .001). Among the 312 infants with isolated CHDs, the 1-year survival rate for the prenatally diagnosed was significantly lower than postnatally diagnosed (77.1% vs 96.1%; P < .001). For isolated CCHDs, the 1-year survival rate for the prenatally diagnosed was significantly lower than postnatally diagnosed (73.4% vs 90.0%; P < .001). The 1-year survival rate was increased with the increase of age at diagnosis. Among infants with isolated CHDs and CCHDs, the adjusted hazard ratios for 1-year mortality rates for the prenatally versus postnatally diagnosed were 2.554 (95% confidence interval [CI], 1.790, 3.654; P < .001) and 2.538 (95% CI: 1.796, 3.699; P < .001), respectively.Prenatal diagnosis is associated with lower 1-year survival rate for infants with isolated CCHDs. This could probably due to variation in the disease severity among the CCHD subtypes.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow diagram for patient enrollment. Note: CCHD = critical congenital heart disease; CHD = congenital heart disease.
Figure 2
Figure 2
One-year survival rate for infants with isolated CHDs by prenatal and postnatal diagnosis. CHD = congenital heart disease.
Figure 3
Figure 3
One-year survival rate for infants with isolated non-CCHDs by prenatal and postnatal diagnosis. CCHD = critical congenital heart disease.
Figure 4
Figure 4
One-year survival rate for infants with isolated CCHDs by prenatal and postnatal diagnosis. CCHD = critical congenital heart disease.
Figure 5
Figure 5
One-year survival rate for infants with isolated CCHDs by age at diagnosis. CCHD = critical congenital heart disease.
See this image and copyright information in PMC

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