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Review
. 2021 Jan 26;11(2):69.
doi: 10.3390/metabo11020069.

The Diabetic Lung: Insights into Pulmonary Changes in Children and Adolescents with Type 1 Diabetes

Chiara Mameli  1   2 , Michele Ghezzi  1   3 , Alessandra Mari  1 , Giulia Cammi  1 , Maddalena Macedoni  1 , Francesca Chiara Redaelli  1 , Valeria Calcaterra  1   4 , Gianvincenzo Zuccotti  1   2 , Enza D'Auria  1   3
Affiliations
Review

The Diabetic Lung: Insights into Pulmonary Changes in Children and Adolescents with Type 1 Diabetes

Chiara Mameli et al. Metabolites. .

Abstract

Historically, the lung was not listed and recognized as a major target organ of diabetic injury. The first evidence of diabetic lung involvement was published fifty years ago, with a study conducted in a population of young adults affected by type 1 diabetes (T1D). In recent years, there has been mounting evidence showing that the lung is a target organ of diabetic injury since the beginning of the disease-at the pediatric age. The deeply branched vascularization of the lungs and the abundance of connective tissue, indeed, make them vulnerable to the effects of hyperglycemia, in a way similar to other organs affected by microvascular complications. In this review, we focus on pulmonary function impairment in children and adolescents affected by T1D. We also cover controversial aspects regarding available studies and future perspectives in this field.

Keywords: children; diabetes-related complications; diabetic lung injury; pulmonary function; type 1 diabetes.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Biochemical mechanisms and signaling pathways potentially involved in diabetes-related lung damage.
See this image and copyright information in PMC

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