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. 2021 Jan 1;14(1):133-139.
eCollection 2021.

Aitongxiao improves pain symptoms of rats with cancer pain by reducing IL-1, TNF-α, and PGE2

Mao Mao  1 , Yanhui Li  2 , Le Wang  3 , Jingxia Chen  4 , Xia Ming  5 , Yonghao Sun  1 , Yanping Lu  1 , Jiao Ning  1
Affiliations

Aitongxiao improves pain symptoms of rats with cancer pain by reducing IL-1, TNF-α, and PGE2

Mao Mao et al. Int J Clin Exp Pathol. .

Abstract

Objective: To explore the mechanism of Aitongxiao in improving pain symptoms of rats with cancer pain.

Methods: Walker 256 breast cancer cells were injected into the right tibial bone marrow cavity of normal female rats to establish a rat model of tibial cancer pain. The rats with successful model replication were randomly divided into normal group (NG), Hank solution group (HSG), cancer pain model group (CPMG), and Aitongxiao+cancer pain model group (ATX+CPMG). The pain response score, mechanical pain hindpaw withdrawal threshold, and latent heat pain of rats were evaluated, and the changes of serum IL-1β, TNF-α, PGE2 and blood cell counts of rats were detected.

Results: Compared with the NG, the pain response score was increased, the mechanical pain hindpaw withdrawal threshold and latent heat pain were decreased, and IL-1β, TNF-α, and PGE2 were increased in CPMG. Compared with the CPMG, the pain response score was decreased, the mechanical pain hindpaw withdrawal threshold and latent heat pain were increased, and IL-1β, TNF-α, and PGE2 were decreased in ATX+CPMG. There was no significant change in blood cell count in each group.

Conclusion: Aitongxiao can improve the pain symptoms of rats with tibial cancer pain. Its mechanism may be related to the reduction of IL-1β, TNF-α, and PGE2 levels.

Keywords: Aitongxiao; IL-1β; PGE2; TNF-α.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Aitongxiao down-regulated serum IL-1β, serum TNF-α and serum PGE2. A: Levels of serum IL-1β in each group. B: Levels of serum TNF-α in each group. C: Levels of serum PGE2 in each group. ns, P>0.05, *P<0.05, **P<0.01.
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