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. 2021 Feb 1;12(1):3-6.
doi: 10.14336/AD.2020.0831. eCollection 2021 Feb.

Coronavirus Disease (COVID-19): A Perspective from Immunosenescence

Miguel Genebat  1   2 , Laura Tarancón-Díez  3 , Rebeca de Pablo-Bernal  4 , Alba Calderón  1 , Mª Ángeles Muñoz-Fernández  3 , Manuel Leal  5
Affiliations

Coronavirus Disease (COVID-19): A Perspective from Immunosenescence

Miguel Genebat et al. Aging Dis. .
No abstract available

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Figures

Figure 1.
Figure 1.
Figurative kinetics of adaptive and innate immune system response against SARS-CoV2 and disease evolution and outcome based on the degree of baseline thymopoiesis status. Left panels: baseline status for naïve T-cell output, peripheral TCR repertoire diversity, neo-antigen response, Treg-cells generation and monocyte cytokine production in patients with preserved (A) and impaired thymopoiesis and comorbidities due to ageing (B). Multiple degrees of variability can be included from A to B status. Right panels: temporal evolution for viral load, cytokine storm, type-I-IFN response, NK-lymphocyte levels, Treg cells, CTL and antibody level following exposure to SARS-CoV2 infection. Likely disease outcome is also indicated. IFN: interferon. Treg: regulatory T-cell. NK lymphocyte: Natural Killer lymphocyte. CTL: cytotoxic T lymphocyte. TCR: T-cell receptor.
See this image and copyright information in PMC

References

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