Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Feb 1;12(1):247-260.
doi: 10.14336/AD.2020.0410. eCollection 2021 Feb.

The Role of Immune Cells in the Pathogenesis of Idiopathic Inflammatory Myopathies

Lijuan Zhao  1 , Qi Wang  2 , Bin Zhou  3 , Lihua Zhang  4 , Honglin Zhu  1
Affiliations
Review

The Role of Immune Cells in the Pathogenesis of Idiopathic Inflammatory Myopathies

Lijuan Zhao et al. Aging Dis. .

Abstract

Idiopathic inflammatory myopathies (IIMs) are chronic autoimmune disorders involving multiple organs, such as the muscle, skin, lungs and joints. Although the detailed pathogenesis of IIMs remains unclear, immune mechanisms have long been recognised as of key importance. Immune cells contribute to many inflammatory processes via intercellular interactions and secretion of inflammatory factors, and many studies have demonstrated the participation of a variety of immune cells, such as T cells and B cells, in the development of IIMs. Here, we summarise the current knowledge regarding immune cells in IIM patients and discuss their potential roles in IIM pathogenesis.

Keywords: Idiopathic inflammatory myopathies; immune cells; pathogenesis.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest The authors declare no conflicts of interest.

References

    1. Amici DR, Pinal-Fernandez I, Pagkatipunan R, Mears A, de Lorenzo R, Tiniakou E et al. (2019). Muscle endurance deficits in myositis patients despite normal manual muscle testing scores. Muscle Nerve,59:70-5. - PMC - PubMed
    1. Alexanderson H, Regardt M, Ottosson C, Alemo Munters L, Dastmalchi M, Dani L et al. (2018). Muscle Strength and Muscle Endurance During the First Year of Treatment of Polymyositis and Dermatomyositis: A Prospective Study. J Rheumatol,45:538-46. - PubMed
    1. Alemo Munters L, Dastmalchi M, Katz A, Esbjornsson M, Loell I, Hanna B et al. (2013). Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis. Arthritis Res Ther,15:R83. - PMC - PubMed
    1. Lundberg IE, de Visser M, Werth VP (2018). Classification of myositis. Nat Rev Rheumatol,14:269-78. - PubMed
    1. Gao S, Luo H, Zhang H, Zuo X, Wang L, Zhu H (2017). Using multi-omics methods to understand dermatomyositis/polymyositis. Autoimmun Rev,16:1044-8. - PubMed

LinkOut - more resources