Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jan;10(1):475-482.
doi: 10.21037/tau-20-665.

A review of nephrotic syndrome and atopic diseases in children

Yue Zheng  1 , Ling Hou  1 , Xiu-Li Wang  1 , Cheng-Guang Zhao  1 , Yue Du  1
Affiliations
Review

A review of nephrotic syndrome and atopic diseases in children

Yue Zheng et al. Transl Androl Urol. 2021 Jan.

Abstract

Pediatric nephrotic syndrome (NS) is a common and recurrent glomerular disease in childhood. Furthermore, 50-70% of children with NS have increased total IgE in peripheral blood and a variety of clinical manifestations of atopic diseases. Hence, NS has many similarities with atopic diseases. However, no study has revealed a clear link between these two diseases. The present review discusses the correlation between pediatric NS and atopic diseases in children from three aspects: pathogenesis, cytokine change, and treatment. There are similar changes in T cells in terms of pathogenesis, with Th1/Th2 dysfunction and Treg cell function downregulation. Cytokine changes are similar and manifest as an increase in Th2 cytokines, TNF-α and TGF-β1, and a decrease in IL-10. Glucocorticoids, immunosuppressants and biological agents are used for the treatment of these two diseases. Therefore, it was speculated that NS and atopic diseases may be the same kind of disease, have a similar pathogenesis, and only exhibit different clinical manifestations due to different affected parts of the disease.

Keywords: Pediatric; atopic diseases; clinical manifestations; nephrotic syndrome (NS); review.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tau-20-665). The authors have no conflicts of interest to declare.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Berghea EC, Balgradean M, Popa IL. Correlation Between Idiopathic Nephrotic Syndrome and Atopy in Children - Short Review. Maedica (Bucur) 2017;12:55-8. - PMC - PubMed
    1. Davin JC. The glomerular permeability factors in idiopathic nephrotic syndrome. Pediatr Nephrol 2016;31:207-15. 10.1007/s00467-015-3082-x - DOI - PMC - PubMed
    1. Kanai T, Shiraishi H, Yamagata T, et al. Th2 cells predominate in idiopathic steroid-sensitive nephrotic syndrome. Clin Exp Nephrol 2010;14:578-83. 10.1007/s10157-010-0330-z - DOI - PubMed
    1. Uwaezuoke SN. Steroid-sensitive nephrotic syndrome in children: triggers of relapse and evolving hypotheses on pathogenesis. Ital J Pediatr 2015;41:19. 10.1186/s13052-015-0123-9 - DOI - PMC - PubMed
    1. Dong C. Diversification of t-helper-cell lineages: Finding the family root of IL-17-producing cells. Nat Rev Immunol 2006;6:329-33. 10.1038/nri1807 - DOI - PubMed

LinkOut - more resources