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Case Reports
. 2020 Dec 17:8:83-85.
doi: 10.1016/j.jdcr.2020.12.010. eCollection 2021 Feb.

Acceleration of cutaneous T-cell lymphoma following dupilumab administration

Kristen Russomanno  1   2 , Cynthia Marie Carver DeKlotz  1
Affiliations
Case Reports

Acceleration of cutaneous T-cell lymphoma following dupilumab administration

Kristen Russomanno et al. JAAD Case Rep. .
No abstract available

Keywords: CTCL, cutaneous T-cell lymphoma; IL, interleukin; atopic dermatitis; biologics; cutaneous t-cell lymphoma; drug reaction; dupilumab; monoclonal antibodies; mycosis fungoides.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Clinical image of the chest depicting diffuse xerosis, lichenification, and ichthyosiform scaling.
Fig 2
Fig 2
Clinical image of the dorsal aspect of the hands depicting deep, painful fissures and erosions.
Fig 3
Fig 3
Clinical image of the palmar aspect of the hands, displaying the severity of the fissures, as well as xerosis and scaling.
Fig 4
Fig 4
Hematoxylin-eosin staining of the skin biopsy, displaying a superficial dermal infiltrate of atypical lymphocytes and histiocytes.
Fig 5
Fig 5
Higher magnification of the skin biopsy, highlighting lymphocyte atypia, tagging, and epidermotropism.
See this image and copyright information in PMC

References

    1. Espinosa M.L., Nguyen M.T., Aguirre A.S. Progression of cutaneous T-cell lymphoma after dupilumab: Case review of 7 patients. J Am Acad Dermatol. 2020;83:197–199. - PMC - PubMed
    1. Chiba T., Nagai T., Osada S.I., Manabe M. Diagnosis of mycosis fungoides following administration of dupilumab for misdiagnosed atopic dermatitis. Acta Derm Venereol. 2019;99:818–819. - PubMed
    1. Geskin L.J., Viragova S., Stolz D.B., Fuschiotti P. Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation. Blood. 2015;125:2798–2805. - PMC - PubMed
    1. Geller S., Lebowitz E., Pulitzer M.P. Outcomes and prognostic factors in African American and black patients with mycosis fungoides/Sézary syndrome: Retrospective analysis of 157 patients from a referral cancer center. J Am Acad Dermatol. 2020;83:430–439. - PMC - PubMed
    1. Hinds G.A., Heald P. Cutaneous T-cell lymphoma in skin of color. J Am Acad Dermatol. 2009;60:359–375. - PubMed

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